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| | PKC-theta inhibitor Basic information |
| Product Name: | PKC-theta inhibitor | | Synonyms: | MDK-8650;PKC-theta inhibitor;2,4-Pyrimidinediamine, N4-[[4-(aminomethyl)cyclohexyl]methyl]-5-nitro-N2-[[2-(trifluoromethoxy)phenyl]methyl]-;N4-((4-(Aminomethyl)cyclohexyl)methyl)-5-nitro-N2-(2-(trifluoromethoxy)benzyl)pyrimidine-2,4-diamine;PKC-theta inhibitor 2 | | CAS: | 736048-65-0 | | MF: | C20H25F3N6O3 | | MW: | 454.45 | | EINECS: | | | Product Categories: | | | Mol File: | 736048-65-0.mol |  |
| | PKC-theta inhibitor Chemical Properties |
| Boiling point | 597.1±60.0 °C(Predicted) | | density | 1.356±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 62.5 mg/mL (137.53 mM) | | form | Solid | | pka | 10.27±0.29(Predicted) | | color | White to off-white |
| | PKC-theta inhibitor Usage And Synthesis |
| Uses | PKC-theta inhibitor 2 is a potent and selective PKC-θ inhibitor with an IC50 value of 18 nM[1]. | | IC 50 | PKCθ: 18 nM (IC50) | | References | [1] Cywin CL, et al. Discovery of potent and selective PKC-theta inhibitors. Bioorg Med Chem Lett. 2007 Jan 1;17(1):225-30. DOI:10.1016/j.bmcl.2006.09.056 |
| | PKC-theta inhibitor Preparation Products And Raw materials |
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