EP 009) manufacturers
- EP009
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- $2500.00
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2026-07-27
- CAS:1462951-30-9
- Purity:
- Supply Ability: 10g
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| | EP 009) Basic information |
| Product Name: | EP 009) | | Synonyms: | EP 009);EP009
(EP-009;Cyclododecanone, 2-(hydroxymethyl)-12-methylene- | | CAS: | 1462951-30-9 | | MF: | C14H24O2 | | MW: | 224.34 | | EINECS: | | | Product Categories: | | | Mol File: | 1462951-30-9.mol |  |
| | EP 009) Chemical Properties |
| | EP 009) Usage And Synthesis |
| Description | EP009 is a novel, selective, and orally active inhibitor of JAK3, inducing therapeutic response in T-cell malignancies. | | Uses | EP009 is a JAK3 inhibitor that selectively inhibits IL-2-mediated JAK3 tyrosine phosphorylation (IC50=10-20 μM in Kit225 cells) without affecting IL-3-induced JAK2 phosphorylation (up to 50 μM in BaF/3 cells). EP009 significantly reduced Kit225 cell viability (72 h, LD50=5.0 μM) while having no effect on BaF/3 cells.[1]. | | References | [1] Inhibition of JAK3 with a novel, selective, and orally active small molecule induces therapeutic response in T-cell malignancies |
| | EP 009) Preparation Products And Raw materials |
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