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| | N-Methylolchloroacetamide Basic information |
| | N-Methylolchloroacetamide Chemical Properties |
| Melting point | 100-105 °C(lit.) | | Boiling point | 374.0±27.0 °C(Predicted) | | density | 1.2776 (rough estimate) | | refractive index | 1.5000 (estimate) | | storage temp. | Inert atmosphere,2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 12.63±0.46(Predicted) | | form | Solid | | color | White to Off-White | | Water Solubility | Very soluble in water. Poorly soluble in aliphatic hydrocarbons. | | Sensitive | Hygroscopic | | BRN | 1811765 | | InChI | InChI=1S/C3H6ClNO2/c4-1-3(7)5-2-6/h6H,1-2H2,(H,5,7) | | InChIKey | TXNSZCSYBXHETP-UHFFFAOYSA-N | | SMILES | C(NCO)(=O)CCl | | CAS DataBase Reference | 2832-19-1(CAS DataBase Reference) | | EPA Substance Registry System | 2-Chloro-N-(hydroxymethyl)acetamide (2832-19-1) |
| Hazard Codes | C | | Risk Statements | 34-43-40-20/21/22 | | Safety Statements | 26-27-36/37/39-45 | | RIDADR | UN 3261 8/PG 2 | | WGK Germany | 3 | | RTECS | AB5733000 | | TSCA | TSCA listed | | HazardClass | 8 | | PackingGroup | Ⅱ | | HS Code | 29241990 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Eye Dam. 1
Skin Corr. 1B |
| | N-Methylolchloroacetamide Usage And Synthesis |
| Chemical Properties | White or almost white crystalline powder | | Uses | N-Methylolchloro-acetamide is a preservative in cooling fluids and cosmetics. | | Uses | An organic building block. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals. As dyestuff intermediate . | | Uses | 2-Chloro-N-(hydroxymethyl)acetamide (N-hydroxymethylchloroacetamide) may be used as a reagent in the synthesis of 1-(aminomethyl)-2-methoxynaphthalene hydrochloride and as a amidomethylating reagent for N,N-dialkylanilines (Tscherniac-Einhorn reaction). | | General Description | 2-Chloro-N-(hydroxymethyl)acetamide (N-methylolchloracetamide) is a N-hydroxymethyl derivative of chloroacetamide. One of the method reported for its synthesis is by the reaction of 2-chloracetamide with formaldehyde. It has been reported to be a formaldehyde releaser and an infrequent sensitizer to formaldehyde contact allergy. Influence of short and prolonged exposure of 2-chloro-N-(hydroxymethyl)acetamide (as formaldehyde donor/releaser) on lymph node responses has been investigated. It has high biocide action and is utilized as preservative. |
| | N-Methylolchloroacetamide Preparation Products And Raw materials |
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