5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM manufacturers
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| | 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM Basic information |
| Product Name: | 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM | | Synonyms: | 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM;guanosine 5'-[β,γ-imido]triphosphate trisodium salt;β:γ-imidoguanosine 5'-triphosphate trisodium salt;5μ-Guanylyl-imidodiphosphate hydrate trisodium salt, GMP-PNP, Gpp(NH)p, β:γ-Imidoguanosine 5μ-triphosphate hydrate trisodium salt;Guanosine 5μ-[β,γ-imido]triphosphate hydrate trisodium salt;5′-Guanylyl-imidodiphosphate trisodium salt hydrate;Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate;β:γ-Imidoguanosine 5′-triphosphate trisodium salt hydrate | | CAS: | 148892-91-5 | | MF: | C10H18N6NaO13P3 | | MW: | 546.19 | | EINECS: | | | Product Categories: | | | Mol File: | 148892-91-5.mol |  |
| | 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM Chemical Properties |
| storage temp. | -70°C | | solubility | H2O: 50 mg/mL | | form | powder | | color | white | | biological source | synthetic (organic) | | Water Solubility | H2O: 50mg/mL, clear, colorless | | InChIKey | QGJNRMUNXAROIT-CYCLDIHTSA-K | | SMILES | [Na+].[Na+].[Na+].Nc1nc(O)c2ncn([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)NP(O)([O-])=O)[C@@H](O)[C@H]3O)c2n1 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37 | | WGK Germany | 3 | | F | 10-21 | | Storage Class | 13 - Non Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM Usage And Synthesis |
| Uses | Non-hydrolyzable analog of GTP; the preferred GTP analog to activate ADP-ribosylation factor. | | Uses | Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate has been used: to study K-RAS interactions with the membrane, for the crystallization of Mycobacterium tuberculosis FtsZ, as a translation initiation inhibitor for the analysis of the 48S pre-initiation complex. | | General Description | Guanosine 5′-[β,γ-imido]triphosphate (GMP-PNP, Gpp(NH)p) is a non-hydrolyzable analog of GTP that binds and irreversibly activates G proteins. Gpp(NH)p is used in a variety of applications that involve GTP binding, including GTP-activation, GTP-inhibition, GTP transport, GTP hydrolysis, and GTP structure stabilization. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, guanosine 5′-[β,γ-imido]triphosphate is often used in studies of protein synthesis. Gpp(NH)p is used to activate ADP-ribosylation factors and to modulate G proteins involved in cell signaling, protein synthesis and other metabolic processes. | | Biochem/physiol Actions | Guanosine 5′-[?,γ-imido]triphosphate binds and irreversibly activates G proteins. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, this non-hydrolyzable GTP analog is often used in studies of protein synthesis. |
| | 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM Preparation Products And Raw materials |
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