| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
marketing1@energy-chemical.com |
SB 220025 trihydrochloride manufacturers
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| | SB 220025 trihydrochloride Basic information |
| | SB 220025 trihydrochloride Chemical Properties |
| solubility | H2O: 22 mg/mL | | form | solid | | color | white | | Water Solubility | H2O: 22mg/mL | | InChI | 1S/C18H19FN6.3ClH/c19-13-3-1-12(2-4-13)16-17(15-7-10-22-18(20)24-15)25(11-23-16)14-5-8-21-9-6-14;;;/h1-4,7,10-11,14,21H,5-6,8-9H2,(H2,20,22,24);3*1H | | InChIKey | IPFBHUGKKONHFR-UHFFFAOYSA-N | | SMILES | Cl[H].Cl[H].Cl[H].Nc1nccc(n1)-c2c(ncn2C3CCNCC3)-c4ccc(F)cc4 |
| Hazard Codes | T | | Risk Statements | 25-36/37/38 | | Safety Statements | 26-36-45 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | SB 220025 trihydrochloride Usage And Synthesis |
| Uses | SB 220025 trihydrochloride may be used in p38-mediated cell signaling studies. | | Biological Activity | SB 220025 is a potent, specific inhibitor of human p38 mitogen-activated protein (MAP) kinase, with an IC50 value of 60 nM and 50- to 1000-fold selectivity. SB 220025 reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 reduced the lipopolysaccharide-induced production of TNF at an ED50 value of 7.5 mg/kg. at 30 mg/kg, SB 220025 reduced the expression of TNF and inhibited angiogenesis by ~40%. In a further study, the effects of p38/CSBP MAP kinase inhibition in angiogenesis-dependent chronic inflammatory disease was tested in murine collagen-induced arthritis and SB 220025 was able to prevent the progression of established arthritis. |
| | SB 220025 trihydrochloride Preparation Products And Raw materials |
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