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| | 3-BROMO-4-FLUOROBENZYL BROMIDE Basic information |
| Product Name: | 3-BROMO-4-FLUOROBENZYL BROMIDE | | Synonyms: | 2-BroMo-4-(broMoMethyl)-1-fluorobenzene;2-Bromo-4-(bromomethyl)-1-fluorobenzene, alpha,3-Dibromo-4-fluorotoluene;3-Bromo-4-fluorobenzyl Bromide >;Benzene, 2-bromo-4-(bromomethyl)-1-fluoro- | | CAS: | 78239-71-1 | | MF: | C7H5Br2F | | MW: | 267.92 | | EINECS: | | | Product Categories: | | | Mol File: | 78239-71-1.mol |  |
| | 3-BROMO-4-FLUOROBENZYL BROMIDE Chemical Properties |
| Melting point | 41 °C | | Boiling point | 259.8±25.0 °C(Predicted) | | density | 1.923±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | soluble in Methanol | | form | Solid | | color | White | | Water Solubility | Slightly soluble in water. | | Sensitive | Lachrymatory |
| Hazard Codes | C,T | | RIDADR | 3261 | | HazardClass | 8 | | PackingGroup | II | | HS Code | 2903998090 |
| | 3-BROMO-4-FLUOROBENZYL BROMIDE Usage And Synthesis |
| Uses | 3-Bromo-4-fluorobenzyl bromide is used as a pharmaceutical intermediate. | | Synthesis | General procedure for the synthesis of 3-bromo-4-fluorobenzyl bromide from 3-bromo-4-fluorotoluene: 3-bromo-4-fluorotoluene (6 mL, 48 mmol) and N-bromosuccinimide (2.7 g, 15 mmol) were dissolved in 1,2-dichloroethane, followed by the addition of 2,2'-azobisisobutyronitrile (16 mg, 0.1 mmol) to a 1,2-dichloroethane solution ( 10 mL). The reaction mixture was heated to reflux for 2 hours. After completion of the reaction, it was cooled to room temperature, diluted with 1,2-dichloroethane (40 mL) and washed with water (2 x 50 mL). The organic phase was dried over anhydrous magnesium sulfate and concentrated to a small volume under reduced pressure. The product 3-bromo-4-fluorobenzyl bromide was obtained (yield: 9.2 g, 72% yield). | | References | [1] Patent: US2009/69320, 2009, A1. Location in patent: Page/Page column 71
[2] Journal of medicinal chemistry, 1967, vol. 10, # 1, p. 64 - 66
[3] Patent: US6586633, 2003, B1 |
| | 3-BROMO-4-FLUOROBENZYL BROMIDE Preparation Products And Raw materials |
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