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| | 2,6-Difluoro-4-nitroaniline Basic information |
| Product Name: | 2,6-Difluoro-4-nitroaniline | | Synonyms: | 2,6-Difluoro-4-nitrobenzenamine;4-Amino-3,5-difluoronitrobenzene;2,6-Difluoro-4-nitro-phenylamine;2,6-Difluoro-4-nitroaniline 95+%;Benzenamine, 2,6-difluoro-4-nitro- | | CAS: | 23156-27-6 | | MF: | C6H4F2N2O2 | | MW: | 174.1 | | EINECS: | 200-258-5 | | Product Categories: | Miscellaneous | | Mol File: | 23156-27-6.mol |  |
| | 2,6-Difluoro-4-nitroaniline Chemical Properties |
| Melting point | 160-161℃ | | Boiling point | 293℃ | | density | 1.554 | | Fp | 131℃ | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | crystalline powder | | pka | -1.97±0.20(Predicted) | | color | Bright greenish lemon |
| Hazard Codes | Xi | | HazardClass | IRRITANT-HARMFUL | | HS Code | 2921420090 |
| | 2,6-Difluoro-4-nitroaniline Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 2,6-difluoro-4-nitroaniline from 3,4,5-trifluoronitrobenzene was as follows: 3,4,5-trifluoro-1-nitrobenzene (5 g, 28.4 mmol) was dissolved in a methanol solution of 7N ammonia (30 mL) and the reaction was stirred at 80°C for 2 days. After completion of the reaction, the mixture was cooled to room temperature, diluted with water (50 mL) and extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, washed sequentially with water (2 × 50 mL), dried over anhydrous magnesium sulfate, and subsequently concentrated under reduced pressure. The crude product was purified by fast silica gel column chromatography (eluent ratio of ethyl acetate:hexane=20:80) to afford the target compound 2,6-difluoro-4-nitroaniline (1.53 g, 31% yield). The product was detected by ESI-MS with m/z of 196 ([M+Na]+, 100%); 1H NMR (600 MHz, DMSO-d6) δppm: 7.82-7.95 (m, 2H), 6.86 (s, 2H). | | References | [1] Patent: WO2014/122303, 2014, A1. Location in patent: Page/Page column 28 |
| | 2,6-Difluoro-4-nitroaniline Preparation Products And Raw materials |
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