BT 18

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BT 18 Suppliers list
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Tel: 15026964105
Email: 2881489226@qq.com
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Email: sales@chemegen.com
Company Name: Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd  
Tel: 15317229551
Email: 15151849396@163.com
Company Name: Beijing Jin Ming Biotechnology Co., Ltd.  
Tel: 010-60605840
Email: psaitong@jm-bio.com

BT 18 manufacturers

  • BT18
  • BT18 pictures
  • $30.00
  • 2026-06-08
  • CAS:924811-53-0
  • Purity: 99.32%
  • Supply Ability: 10g
  • BT18
  • BT18 pictures
  • $30.00
  • 2026-06-08
  • CAS:924811-53-0
  • Purity: 99.32%
  • Supply Ability: 10g
BT 18 Basic information
Product Name:BT 18
Synonyms:BT 18;Methanone, [4-[5-[(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)sulfonyl]-2-methoxyphenyl]-1-piperazinyl][4-fluoro-2-(trifluoromethyl)phenyl]-;BT 18,BT-18,BT18,Inhibitor,inhibit;(4-(5-((6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)-2-methoxyphenyl)piperazin-1-yl)(4-fluoro-2-(trifluoromethyl)phenyl)methanone;BT18, 10 mM in DMSO
CAS:924811-53-0
MF:C30H31F4N3O6S
MW:637.64
EINECS:
Product Categories:
Mol File:924811-53-0.mol
BT 18 Structure
BT 18 Chemical Properties
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (156.83 mM; Need ultrasonic)
form Solid
color White to light yellow
Safety Information
MSDS Information
BT 18 Usage And Synthesis
UsesBT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF)[1]. BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function[2].
Biological ActivityBT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF)[1]. BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function[2]. BT18 (50 μM; 1-90 minutes) activates AKT and ERK1/2 in time-dependently in MG87RET cell lines[1].BT18 (1-50 μM; 90 minutes) activates AKT in a dose-dependent manner in MG87RET cell lines[1].BT18 (5-50 μM; 15 mimutes) appears to phosphorylate RET in concentration of 50 μM both in GFP-transfected and in GFRD1-transfected cells[1].
References[1]. Leo Jakman, Characterization of small-molecule GDNF mimics.[2]. Ivanova L, et al. Molecular Dynamics Simulations of the Interactions between Glial Cell Line-DerivedNeurotrophic Factor Family Receptor GFRα1 and Small-Molecule Ligands. ACS Omega. 2018 Sep 30;3(9):11407-11414.
BT 18 Preparation Products And Raw materials
Tag:BT 18(924811-53-0) Related Product Information
Protein Tyrosine Kinase Compound Library 1,4-Pentanediamine, N4-[7-chloro-2-[(1E)-2-(2-chlorophenyl)ethenyl]-4-quinolinyl]-N1,N1-diethyl- Anti-CNTFR Antibody Anti-Artemin antibody Hexadecanoic acid, [4-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-2-formyl-3-hydroxy-5-methoxyphenyl]methyl ester GFRα2/3-IN-1