YZ129 manufacturers
- YZ129
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- $59.00
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2026-04-21
- CAS:1643120-60-8
- Purity:
- Supply Ability: 10g
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| Product Name: | YZ129 | | Synonyms: | YZ129;YZ129 4-(Isoquinolin-6-ylamino)naphthalene-1,2-dione;1,2-Naphthalenedione, 4-(6-isoquinolinylamino)-;4-(Isoquinolin-6-ylamino)naphthalene-1,2-dione | | CAS: | 1643120-60-8 | | MF: | C19H12N2O2 | | MW: | 300.31 | | EINECS: | | | Product Categories: | | | Mol File: | 1643120-60-8.mol |  |
| | YZ129 Chemical Properties |
| Boiling point | 543.3±50.0 °C(Predicted) | | density | 1.411±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 5.6 mg/mL (18.65 mM; ultrasonic and warming and heat to 80°C) | | pka | 6.52±0.10(Predicted) | | form | Solid | | color | Brown to red |
| | YZ129 Usage And Synthesis |
| Uses | YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration[1]. | | IC 50 | HSP90 | | References | [1] Liu Z, et al. Discovery of Small-Molecule Inhibitors of the HSP90-Calcineurin-NFAT Pathway against Glioblastoma. Cell Chem Biol. 2018 Nov 30. pii: S2451-9456(18)30431-8. DOI:10.1016/j.chembiol.2018.11.009 |
| | YZ129 Preparation Products And Raw materials |
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