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Product Name:Pseudouridimycin (PUM)
CAS:1566586-52-4
Purity:98% Package:按需包装
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| | Pseudouridimycin (PUM) Basic information |
| Product Name: | Pseudouridimycin (PUM) | | Synonyms: | Pseudouridimycin (PUM);Pseudouridimycin;2,4(1H,3H)-Pyrimidinedione, 5-[5-[[N-(aminoiminomethyl)glycyl-N2-hydroxy-L-glutaminyl]amino]-5-deoxy-β-D-ribofuranosyl]-;Pseudouridimycine | | CAS: | 1566586-52-4 | | MF: | C17H26N8O9 | | MW: | 486.44 | | EINECS: | | | Product Categories: | | | Mol File: | 1566586-52-4.mol |  |
| | Pseudouridimycin (PUM) Chemical Properties |
| density | 1.91±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 7.75±0.50(Predicted) | | color | Light yellow to yellow |
| | Pseudouridimycin (PUM) Usage And Synthesis |
| Uses | Pseudouridimycine is involved in the study of bacterial RNA polyemerase transcriptiion by trapping the open clamp state. Pseudouridimycin is an antibiotic from a new class of inhibitors that acts against Gram-positive and Gram-negative bacteria. | | in vivo | Pseudouridimycin (3.2-50 mg/kg; iv; 10 min after infection and again 6 h after infection) clears infection in vivo in a mouse Streptococcus pyogenes peritonitis model (ED50 = 9 mg/kg)[3]. | Animal Model: | Female ICR mice (23-25 g) intraperitoneal injection of 0.5 mL saline solution (supplemented with 1% peptone) containing 4 × 103 cfu S. pyogenes C203[3]. | | Dosage: | 3.2 mg/kg, 8 mg/kg, 20 mg/kg, 50 mg/kg | | Administration: | iv; 10 min after infection and again 6 h after infection | | Result: | Showed antibacterial activity in vivo. |
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| | Pseudouridimycin (PUM) Preparation Products And Raw materials |
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