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| | CA9 (D10C10) Rabbit mAb Chemical Properties |
| | CA9 (D10C10) Rabbit mAb Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human | | Background | Carbonic anhydrases are a family of ancient zinc metalloenzymes found in almost all living organisms. All CA can be divided into 3 distinct classes that evolved independently and have no significant homology in sequence and overall folding. All functional CA catalyze the reversible hydration of CO2 into HCO3- and H+ and contain a zinc atom in the active sites essential for catalysis. There are many isoforms of CA in mammals and they all belong to the α class.CA9 is a member of alpha class, a plasma membrane protein with the catalytic domain in the extracellular space. Its expression is restricted to very few normal tissues. CA9 expression is strongly induced by hypoxia and down-regulated by the wildtype von Hippel–Lindau tumor suppressor protein. CA9 expression is increased in many types of tumor, especially in solid hypoxic tumors with a poor responsiveness to the conventional radio-and/or chemo-therapies; CA9 is considered as a tumor hypoxia marker and a promising target for cancer therapeutic intervention. | | References | [1] Smith, K.S. et al. (1999) Proc Natl Acad Sci USA 96, 15184-9.
[2] Tripp, B.C. et al. (2001) J Biol Chem 276, 48615-8.
[3] Potter, C.P. and Harris, A.L. (2003) Br J Cancer 89, 2-7.
[4] Winum, J.Y. et al. (2009) Anticancer Agents Med Chem 9, 693-702.
[5] De Simone, G. and Supuran, C.T. (2010) Biochim Biophys Acta 1804, 404-9. |
| | CA9 (D10C10) Rabbit mAb Preparation Products And Raw materials |
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