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| | CD109 Antibody Chemical Properties |
| | CD109 Antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human | | Background | CD109 is a glycosylphosphatidylinositol-linked glycoprotein that belongs to the alpha2-macroglobulin family of thioester containing proteins. CD109 is associated with TGF-beta receptor I and inhibits TGF-beta signaling. Cleavage of CD109 at its Furin cleavage site results in the release of its large amino-terminal domain, which then binds to the TGF-beta receptor I to inhibit TGF-beta signaling. CD109 is expressed on a subset of CD34+ bone marrow cells and mesenchymal stem cells, activated platelets, activated T cells, endothelial cells, and a wide variety of tumors. Elevated CD109 expression has been considered a diagnostic/prognostic marker for several types of cancers. | | References | [1] Lin, M. et al. (2002) Blood 99, 1683-91.
[2] Finnson, K.W. et al. (2006) FASEB J 20, 1525-7.
[3] Zhang, J.M. et al. (2015) Biochem Biophys Res Commun 459, 252-8.
[4] Hagiwara, S. et al. (2010) Oncogene 29, 2181-91.
[5] Litvinov, I.V. et al. (2011) Exp Dermatol 20, 627-32.
[6] Zhou, S. et al. (2017) Oncotarget 8, 95632-47.
[7] Li, C. et al. (2016) Biochem J 473, 537-47.
[8] Hashimoto, M. et al. (2004) Oncogene 23, 3716-20.
[9] Sato, T. et al. (2007) Pathol Int 57, 719-24.
[10] Qi, R. et al. (2018) J Transl Med 16, 88.
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| | CD109 Antibody Preparation Products And Raw materials |
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