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| Product Name: | GPX4 antibody | | Synonyms: | GPX4 antibody;Rabbit Monoclonal GPX4 Antibody | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![GPX4 antibody Structure]() |
| | GPX4 antibody Chemical Properties |
| | GPX4 antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Monkey | | Background | The selenoprotein glutathione peroxidase 4 is a master regulator of ferroptosis, a form of programmed cell death induced by iron-dependent lipid peroxidation. GPX4 converts lipid hydroperoxides to non-toxic lipid alcohols, therefore preventing ferroptosis. Research studies show that selenium enhances GPX4 expression and inhibits ferroptotic death to protect neurons. In addition, some therapy-resistant cancer cells depend on GPX4 to survive. Loss of GPX4 leads to ferroptosis and thus prevents tumor relapse in mice. Furthermore, redox homeostasis mediated by GPX4 is essential for activation of the cytosolic DNA-sensing cGAS-STING pathway and initiation of the subsequent innate immune response. | | References | [1] Wenzel, S.E. et al. (2017) Cell 171, 628-641.e26.
[2] Bersuker, K. et al. (2019) Nature 575, 688-92.
[3] Alim, I. et al. (2019) Cell 177, 1262-1279.e25.
[4] Hangauer, M.J. et al. (2017) Nature 551, 247-50.
[5] Jia, M. et al. (2020) Nat Immunol 21, 727-35. |
| | GPX4 antibody Preparation Products And Raw materials |
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