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| Product Name: | MEK1 antibody | | Synonyms: | MEK1 antibody;Rabbit Monoclonal MEK1 Antibody | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![MEK1 antibody Structure]() |
| | MEK1 antibody Chemical Properties |
| | MEK1 antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat;Monkey | | Background | MEK1 and MEK2, also called MAPK or Erk kinases, are dual-specificity protein kinases that function in a mitogen activated protein kinase cascade controlling cell growth and differentiation. Activation of MEK1 and MEK2 occurs through phosphorylation of two serine residues at positions 217 and 221, located in the activation loop of subdomain VIII, by Raf-like molecules. MEK1/2 is activated by a wide variety of growth factors and cytokines and also by membrane depolarization and calcium influx. Constitutively active forms of MEK1/2 are sufficient for the transformation of NIH/3T3 cells or the differentiation of PC-12 cells. MEK activates p44 and p42 MAP kinase by phosphorylating both threonine and tyrosine residues at sites located within the activation loop of kinase subdomain VIII. | | References | [1] Crews, C.M. et al. (1992) Science 258, 478-480.
[2] Alessi, D.R. et al. (1994) EMBO J. 13, 1610-19.
[3] Rosen, L.B. et al. (1994) Neuron 12, 1207-21.
[4] Cowley, S. et al. (1994) Cell 77, 841-52. |
| | MEK1 antibody Preparation Products And Raw materials |
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