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| | Phospho-Stat1 (Ser727) Antibody Chemical Properties |
| | Phospho-Stat1 (Ser727) Antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat;Monkey | | Background | The Stat1 transcription factor is activated in response to a large number of ligands and is essential for responsiveness to IFN-α and IFN-γ. Phosphorylation of Stat1 at Tyr701 induces Stat1 dimerization, nuclear translocation, and DNA binding. Stat1 protein exists as a pair of isoforms, Stat1α and the splice variant Stat1β. In most cells, both isoforms are activated by IFN-α, but only Stat1α is activated by IFN-γ. The inappropriate activation of Stat1 occurs in many tumors. In addition to tyrosine phosphorylation, Stat1 is also phosphorylated at Ser727 through a p38 mitogen-activated protein kinase-dependent pathway in response to IFN-α and other cellular stresses. Serine phosphorylation may be required for the maximal induction of Stat1-mediated gene activation. | | References | [1] Heim, M.H. (1999) J Recept Signal Transduct Res 19, 75-120.
[2] Durbin, J.E. et al. (1996) Cell 84, 443-50.
[3] Meraz, M.A. et al. (1996) Cell 84, 431-42.
[4] Ihle, J.N. et al. (1994) Trends Biochem Sci 19, 222-7.
[5] Frank, D.A. (1999) Mol Med 5, 432-56.
[6] Wen, Z. et al. (1995) Cell 82, 241-50. |
| | Phospho-Stat1 (Ser727) Antibody Preparation Products And Raw materials |
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