| Company Name: |
Novus Biologicals
|
| Tel: |
400821347 |
| Email: |
orders@novusbio.com |
| Products Intro: |
Product Name:PRAS40 Antibody
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| Company Name: |
GeneTex, Inc.
|
| Tel: |
0755-26755892 1-949-553-1900 |
| Email: |
international@genetex.com |
| Products Intro: |
Product Name:PRAS40 antibody
|
| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Email: |
Enzoname@qq.com |
| Products Intro: |
Product Name:PRAS40 Antibody
|
| Company Name: |
Abmart Inc
|
| Tel: |
4006-123-828 13162017139 |
| Email: |
market@ab-mart.com |
| Products Intro: |
Product Name:PRAS40 Antibody
|
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| | PRAS40 antibody Chemical Properties |
| | PRAS40 antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat;Monkey | | Background | Many growth factors and hormones induce the phosphoinositide 3-kinase signaling pathway, which results in the activation of downstream effector proteins such as the serine/threonine kinase Akt. One known Akt substrate is a 40 kDa, proline-rich protein that binds to 14-3-3 proteins. PRAS40 also binds mTOR to transduce Akt signals to the mTOR complex. Inhibition of mTOR signaling stimulates PRAS40 binding to mTOR, which in turn inhibits mTOR activity. PRAS40 interacts with raptor in mTOR complex 1 in insulin-deprived cells and inhibits the activation of the mTORC1 pathway mediated by the cell cycle protein Rheb. Phosphorylation of PRAS40 by Akt at Thr246 relieves PRAS40 inhibition of mTORC1. mTORC1 in turn phosphorylates PRAS40 at Ser183. | | References | [1] Cantley, L.C. (2002) Science 296, 1655-7.
[2] Kovacina, K.S. et al. (2003) J Biol Chem 278, 10189-94.
[3] Vander Haar, E. et al. (2007) Nat Cell Biol 9, 316-23.
[4] Sancak, Y. et al. (2007) Mol Cell 25, 903-15.
[5] Oshiro, N. et al. (2007) J Biol Chem 282, 20329-39. |
| | PRAS40 antibody Preparation Products And Raw materials |
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