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| Product Name: | RAN antibody | | Synonyms: | RAN antibody;Mouse Monoclonal RAN Antibody | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![RAN antibody Structure]() |
| | RAN antibody Chemical Properties |
| | RAN antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat;Hamster;Monkey;Bovine | | Background | Ran is a small GTPase of the Ras family that plays a central role in the spacial and temperal organization of eukaryotic cells. During interphase, Ran-GDP localizes to the cytoplasm and Ran-GTP to the nucleus. This polarized localization of Ran ensures its role in nuclear transport. During mitosis, Ran-GTP is chromatin associated, where it promotes spindle assembly and nuclear envolope formation. In S phase, Ran-GTP associates with and inhibits MCM helicase, ensuring precise chromosomal DNA duplication during the cell cycle. | | References | [1] Quimby, B.B. and Dasso, M. (2003) Curr. Opin. Cell Biol. 15, 338-344.
[2] Hetzer, M. et al. (2002) Nat. Cell Biol. 4, 177-184.
[3] Yamaguchi, R. and Newport, J. (2003) Cell 113, 115-125. |
| | RAN antibody Preparation Products And Raw materials |
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