| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:HS79
CAS:2138838-56-7
Package:25mg/RMB 10600;50mg/RMB 13800;100mg/RMB 17500
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HS79 manufacturers
- HS79
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- $1520.00 / 25mg
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2024-10-28
- CAS:2138838-56-7
- Min. Order:
- Purity:
- Supply Ability: 10g
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| Product Name: | HS79 | | Synonyms: | HS79;HS79,HS-79;Thieno[2,3-d]pyrimidin-4-amine, 5,6-dimethyl-N-[(3R)-1-(phenylmethyl)-3-pyrrolidinyl]-;N-[(3R)-1-Benzylpyrrolidin-3-yl]-5,6-dimethylthieno[2,3-d]pyrimidin-4-amine | | CAS: | 2138838-56-7 | | MF: | C19H22N4S | | MW: | 338.47 | | EINECS: | | | Product Categories: | | | Mol File: | 2138838-56-7.mol |  |
| Boiling point | 519.0±50.0 °C(Predicted) | | density | 1.274±0.06 g/cm3(Predicted) | | pka | 8.67±0.40(Predicted) |
| Uses | HS-79 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-79 is able to inhibit the incorporation of tritiated acetate into lipids with an IC50 of 1.57 μM. | | Definition | ChEBI: (R)-Fasnall is an N-(1-benzylpyrrolidin-3-yl)-5,6-dimethylthieno[2,3-d]pyrimidin-4-amine in which the chiral centre has R configuration. Both enantiomers act as fatty acid synthase inhibitors, although the (S)-enantiomer was found to be more than 4 times as active as the (R)-enantiomer. It has a role as a fatty acid synthesis inhibitor and an EC 2.3.1.85 (fatty acid synthase) inhibitor. It is an enantiomer of a (S)-Fasnall. | | References | [1] Alwarawrah Y, et al. Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer. Cell Chem Biol. 2016 Jun 23;23(6):678-88. DOI:10.1016/j.chembiol.2016.04.011 |
| | HS79 Preparation Products And Raw materials |
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