Homocarbonyltopsentin
| 中文名称 | Homocarbonyltopsentin |
|---|---|
| 中文同义词 | 化合物 T13723;化合物 HOMOCARBONYLTOPSENTIN |
| 英文名称 | Homocarbonyltopsentin |
| 英文同义词 | Homocarbonyltopsentin;PK4C9;Methanone, [2-[(6-hydroxy-1H-indol-3-yl)carbonyl]-1H-imidazol-4-yl]-1H-indol-3-yl- (9CI) |
| CAS号 | 172286-77-0 |
| 分子式 | C21H14N4O3 |
| 分子量 | 370.36 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 172286-77-0.mol |
| 结构式 |  |
Homocarbonyltopsentin 性质
| 熔点 | >210 °C |
|---|---|
| 沸点 | 801.2±75.0 °C(Predicted) |
| 密度 | 1.539±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：125 mg/ml（337.51 mM） |
| 酸度系数(pKa) | 7.50±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至黄色 |
| InChI | 1S/C21H14N4O3/c26-11-5-6-13-15(9-23-17(13)7-11)20(28)21-24-10-18(25-21)19(27)14-8-22-16-4-2-1-3-12(14)16/h1-10,22-23,26H,(H,24,25) |
| InChIKey | DRCVQVIMGSWRLN-UHFFFAOYSA-N |
| SMILES | [nH]1c(nc(c1)C(=O)c4c5c([nH]c4)cccc5)C(=O)c2c3c([nH]c2)cc(cc3)O |
Homocarbonyltopsentin (PK4C9) 是结合 TSL2 的小分子化合物，高羰基形成蛋白，
与 TSL2 的 pentaloop 构象结合并促进向三叶草构象的转变，增强 SMN2 外显子7 (E7) 剪接，EC50 值为 16 μM。
Homocarbonyltopsentin (PK4C9) (10-40 μM; 24 hours) shows an up to 5.2-fold decrease in the expression of E7-excluding SMN2 isoforms, and up to three-fold increase in E7-including isoforms in GM03813C cells. Homocarbonyltopsentin (PK4C9) (40 μM; 24 hours) increased 1.5-fold SMN protein expression compared to GM03813C cells treated with DMSO.
RT-PCR
| Cell Line: | GM03813C (SMA) cells; GM03814B fibroblasts cells |
| Concentration: | 10-40 μM |
| Incubation Time: | 24 hours |
| Result: | E7 inclusion reached a maximum of 91% (25% increase, DMSO-treated cells). |
Western Blot Analysis
| Cell Line: | GM03813C (SMA) cells; GM03814B fibroblasts cells |
| Concentration: | 40 μM |
| Incubation Time: | 24 hours |
| Result: | Increased SMN protein in SMA cells. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-117389 | Homocarbonyltopsentin Homocarbonyltopsentin | 172286-77-0 | 5mg | 2200元 |
| 2026/09/15 | HY-117389 | Homocarbonyltopsentin Homocarbonyltopsentin | 172286-77-0 | 10mM * 1mLin DMSO | 2420元 |