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| | (1-METHYL-1H-INDOL-5-YL)METHYLAMINE Basic information |
| Product Name: | (1-METHYL-1H-INDOL-5-YL)METHYLAMINE | | Synonyms: | (1-METHYL-1H-INDOL-5-YL)METHYLAMINE;[(1-Methyl-1H-indol-5-yl)methyl]amine acetate;5-Aminomethyl-1-methylindole;(1-methyl-1H-indol-5-yl)methanamine acetate;(1-Methyl-1H-indol-5-yl);1H-Indole-5-methanamine, 1-methyl-;1-Methylindole-5-methanamine;(1-methylindol-5-yl)methanamine | | CAS: | 884507-17-9 | | MF: | C10H12N2 | | MW: | 160.22 | | EINECS: | | | Product Categories: | | | Mol File: | 884507-17-9.mol |  |
| | (1-METHYL-1H-INDOL-5-YL)METHYLAMINE Chemical Properties |
| Melting point | 55 °C | | Boiling point | 319.4±17.0 °C(Predicted) | | density | 1.11±0.1 g/cm3 (20 ºC 760 Torr) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | solid | | pka | 9.27±0.40(Predicted) | | Appearance | Off-white to yellow Solid | | InChI | 1S/C10H12N2/c1-12-5-4-9-6-8(7-11)2-3-10(9)12/h2-6H,7,11H2,1H3 | | InChIKey | XYCZKICJSDSNOW-UHFFFAOYSA-N | | SMILES | Cn1ccc2cc(CN)ccc12 |
| Risk Statements | 22-34 | | Safety Statements | 22-26-36/37/39-45 | | WGK Germany | WGK 3 | | HazardClass | IRRITANT | | Storage Class | 11 - Combustible Solids |
| | (1-METHYL-1H-INDOL-5-YL)METHYLAMINE Usage And Synthesis |
| Definition | ChEBI: (1-Methyl-1H-indol-5-yl)methylamine is a member of indoles. | | Synthesis | Step 2: 1-methyl-1H-indole-5-carbonitrile (800 mg, 5.12 mmol) was dissolved in a methanol solution of 7 M ammonia (50 mL) and Raney Ni (2.0 g) was added. The reaction mixture was stirred vigorously at room temperature for 18 h under hydrogen (1 atm) atmosphere. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated under vacuum to give 800 mg of (1-methyl-1H-indol-5-yl)methylamine (296), the product was a yellow oil. Mass spectrum (ESI) m/z = 144.3 [M-NH2]+. | | References | [1] Journal of Medicinal Chemistry, 2007, vol. 50, # 15, p. 3651 - 3660
[2] Patent: WO2013/26914, 2013, A1. Location in patent: Page/Page column 169
[3] Organic and Biomolecular Chemistry, 2013, vol. 11, # 36, p. 6003 - 6007 |
| | (1-METHYL-1H-INDOL-5-YL)METHYLAMINE Preparation Products And Raw materials |
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