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Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]- manufacturers
- A6770
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- $1850.00
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2026-05-11
- CAS:1331754-16-5
- Purity:
- Supply Ability: 10g
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| | Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]- Basic information |
| | Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]- Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,PBS (pH 7.2): 10 mg/ml | | form | A crystalline solid | | color | White to off-white |
| | Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]- Usage And Synthesis |
| Uses | A6770 is an orally active, potent sphingosine 1-phosphate (S1P) lyase (S1PL) inhibitor. A6770 is phosphorylated and the phosphorylated form directly inhibits S1P lyased.A6770, a potential key metabolite of THI, induces a [3H]dhS1P increase[1][2]. | | Biological Activity | A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.1 It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P lyase (EC50 = <0.01 μM), an effect that is reduced in the presence of vitamin B6 (EC50 = <100 μM). | | in vivo | A6770 (1, 10, 100mg/kg; po; single dose) induces reductions in peripheral lymphocyte number in rats[2] | | References | 1.Ohtoyo, M., Tamura, M., Machinaga, N., et al.Scintillation proximity assay to detect the changes in cellular dihydrosphingosine 1-phosphate levelsLipids51(10)1207-1216(2016) |
| | Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]- Preparation Products And Raw materials |
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