| Company Name: |
Shanghai Universal Biotech Co.,Ltd
|
| Tel: |
15921930842 15921930842 |
| Email: |
yh-wang@univ-bio.com |
| Products Intro: |
Product Name:Phospho-STING (Ser365) (D8F4W) Rabbit mAb
Purity:见优宁维官网 Package:100ul/RMB 1
|
| Company Name: |
Cell Signaling Technology Inc
|
| Tel: |
21-80243558 86218024 |
| Email: |
info@cellsignal.cn |
| Products Intro: |
Product Name:Phospho-STING (Ser365) (D8F4W) Rabbit mAb
|
|
| | Phospho-STING (Ser365) (D8F4W) Rabbit mAb Chemical Properties |
| | Phospho-STING (Ser365) (D8F4W) Rabbit mAb Usage And Synthesis |
| Source | Rabbit | | Reactivity | Mouse | | Background | Stimulator of interferon genes is a transmembrane adaptor protein that is a critical component of the cellular innate immune response to pathogenic cytoplasmic DNA. STING is a ubiquitously expressed protein found predominantly in the ER. The enzyme cGAMP synthase produces the second messenger cyclic-GMP-AMP in response to cytoplasmic DNA. cGAMP binds and activates STING. In addition, detection of cytoplasmic DNA by nucleic acid sensors, including DDX41 or IFI16, results in STING activation. Following activation, STING translocates with TBK1 to perinuclear endosomes. The TBK1 kinase phosphorylates and activates interferon regulatory factors and NF-κB, which leads to the induction of type I interferon and other immune response genes.Following binding of cyclic dinucleotides, STING is phosphorylated by TBK1 at Ser366, leading to IRF-3 activation and type I interferon upregulation. | | References | [1] Ishikawa, H. and Barber, G.N. (2008) Nature 455, 674-8.
[2] Zhong, B. et al. (2008) Immunity 29, 538-50.
[3] Sun, L. et al. (2013) Science 339, 786-91.
[4] Wu, J. et al. (2013) Science 339, 826-30.
[5] Zhang, Z. et al. (2011) Nat Immunol 12, 959-65.
[6] Unterholzner, L. et al. (2010) Nat Immunol 11, 997-1004.
[7] Ishikawa, H. et al. (2009) Nature 461, 788-92.
[8] Liu, S. et al. (2015) Science 347, aaa2630. |
| | Phospho-STING (Ser365) (D8F4W) Rabbit mAb Preparation Products And Raw materials |
|