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| | XCR1 (D2F8T) Rabbit mAb Chemical Properties |
| | XCR1 (D2F8T) Rabbit mAb Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human | | Background | X-C motif chemokine receptor 1, part of the G protein-coupled superfamily, is expressed by a subset of dendritic cells and acts as a receptor for chemokines XCL1 and XCL2. XCR1-positive dendritic cells cross-present antigens to naïve CD8+ T cells, priming them to become activated cytotoxic CD8+ T cells. In mouse models, the XCL1-XCR1 signaling axis was shown to be involved in the formation of self-tolerance through the development of Treg cells within the thymus. | | References | [1] Yoshida, T. et al. (1998) J Biol Chem 273, 16551-4.
[2] Fox, J.C. et al. (2015) Cytokine 71, 302-11.
[3] Dorner, B.G. et al. (2009) Immunity 31, 823-33.
[4] Kroczek, R.A. and Henn, V. (2012) Front Immunol 3, 14.
[5] Bachem, A. et al. (2010) J Exp Med 207, 1273-81.
[6] Lei, Y. et al. (2011) J Exp Med 208, 383-4. |
| | XCR1 (D2F8T) Rabbit mAb Preparation Products And Raw materials |
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