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| | KAEMPFEROL-3-O-RUTINOSIDE Basic information |
| | KAEMPFEROL-3-O-RUTINOSIDE Chemical Properties |
| Melting point | 200°C (dec.) | | Boiling point | 941.7±65.0 °C(Predicted) | | density | 1.76 | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 6.20±0.40(Predicted) | | color | Off-White to Yellow | | biological source | plant (Clematis cultivar) | | Stability: | Hygroscopic | | InChIKey | RTATXGUCZHCSNG-FVJKAJKWNA-N | | SMILES | C1(O[C@H]2[C@H](O)[C@H]([C@H](O)[C@@H](CO[C@@H]3O[C@H]([C@H](O)[C@@H](O)[C@H]3O)C)O2)O)C(=O)C2=C(C=C(O)C=C2O)OC=1C1C=CC(O)=CC=1 |&1:2,3,5,6,8,11,13,14,16,18,r| |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 22-45-24/25 | | WGK Germany | 3 | | HS Code | 29389090 |
| | KAEMPFEROL-3-O-RUTINOSIDE Usage And Synthesis |
| Description | Nicotiflorin is a flavonoid that has been found in I. glandulifera and has antioxidant and neuroprotective activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and ABTS radicals with EC50 values of 0.52 and 0.48 mg/ml, respectively, in cell-free assays. Nicotiflorin (1 μM) prevents hydrogen peroxide-induced decreases in tyrosine hydroxylase activity in PC12 cells and cell death in primary rat mesencephalic neurons. It decreases infarct volume by 24.5, 45.8, and 63.2% when administered at doses of 2.5, 5, and 10 mg/kg, respectively, in a rat model of cerebral ischemia-reperfusion injury induced by transient middle central artery occlusion (MCAO). | | Uses | Kaempferol 3-O-β -Rutinoside is a flavonoid antioxidant compound from Cichorium spinosum L. ecotype plants and also may display anti-diabetic activity. It is a component of many plant species including Helianthemum ruficomum. | | Definition | ChEBI: Kaempferol-3-rutinoside is a kaempferol O-glucoside that is kaempferol attached to a rutinosyl [6-deoxy-alpha-L-mannosyl-(1->6)-beta-D-glucosyl] residue at position 3 via a glycosidic linkage. It has been isolated from the leaves of Solanum campaniforme. It has a role as a metabolite, a radical scavenger and a plant metabolite. It is a rutinoside, a trihydroxyflavone, a disaccharide derivative and a kaempferol O-glucoside. | | General Description | Kaempferol 3-O-β -rutinoside is a bitter tasting flavonol glycoside that was isolated from flowers of a Clematis cultivar. | | in vivo | At doses of 2.5, 5 and 10 mg/kg, nicotiflorin administered immediately after the onset of ischemia markedly reduces brain infarct volume and neurological deficits[2]. Nicotiflorin (2.5-10 mg/kg) administered after onset of ischemia markedly reduces brain infarct volume by 24.5-63.2% and neurological deficits[3]. | | References | [1] KATARZYNA SZEWCZYK . Phenolic constituents of the aerial parts of Impatiens glandulifera Royle (Balsaminaceae) and their antioxidant activities[J]. Natural Product Research, 2019, 33 19: Pages 2851-2855. DOI: 10.1080/14786419.2018.1499644
[2] WEI QU . Kaempferol Derivatives Prevent Oxidative Stress–Induced Cell Death in a DJ-1–Dependent Manner[J]. Journal of pharmacological sciences, 2009, 110 2: Pages 191-200. DOI: 10.1254/jphs.09045fp
[3] RUNPING LI . Nicotiflorin reduces cerebral ischemic damage and upregulates endothelial nitric oxide synthase in primarily cultured rat cerebral blood vessel endothelial cells[J]. Journal of ethnopharmacology, 2006, 107 1: Pages 143-150. DOI: 10.1016/j.jep.2006.04.024 |
| | KAEMPFEROL-3-O-RUTINOSIDE Preparation Products And Raw materials |
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