4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID CAS#: 170846-89-6

4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID

生物活性靶点体外研究体内研究用途与合成方法 MSDS 4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID价格(试剂级) 上下游产品信息

中文名称	4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID
中文同义词	化合物E4CPG
英文名称	E4CPG
英文同义词	E4CPG;(RS)-ALPHA-ETHYL-4-CARBOXYPHENYLGLYCINE;(RS)-α-Ethyl-4-carboxyphenylglycine;4-(1-amino-1-carboxypropyl)benzoic acid;Benzeneacetic acid, α-amino-4-carboxy-α-ethyl-;Metabotropic glutamate receptors,metabotropic,Inhibitor,mGluR,mGluRs,inhibit,(RS)-ECPG,E4CPG,E-4CPG
CAS号	170846-89-6
分子式	C11H13NO4
分子量	223.23
EINECS号
相关类别	Glutamate receptor
Mol文件	Mol File
结构式

4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID 性质

沸点	431.3±40.0 °C(Predicted)
密度	1.337±0.06 g/cm3(Predicted)
储存条件	Store at RT
溶解度	H2O：< 0.1 mg/mL（不溶）DMSO：< 1 mg/mL（不溶或微溶）
形态	粉末
酸度系数(pKa)	1.76±0.10(Predicted)
颜色	白色至米白色

4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID 用途与合成方法

生物活性

E4CPG ((RS)-ECPG) 是一种 Group I/Group II 代谢型谷氨酸受体 (Group I/Group II metabotropic glutamate receptor) 的拮抗剂。E4CPG 可以抑制单突触后机制中突触后电流 (IPSC) 增强的成对脉冲比。

靶点

mGluR

体外研究

E4CPG acts at rat cortical mGluR with the K _B value of 0.367 mM.

体内研究

E4CPG (3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.), and 1-10 nmol/site (i.c.v.)) significantly inhibits the nociception induced by the Glutamate-injection (i.pl.; 30 μmol/paw), and the maximal inhibition values for the antinociceptive action of E4CPG in Glutamate-induced nociception are 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.) .
E4CPG (35 nM/3.5 μL, i.c.v.) completely blocks long-term depression (LTD) induced by the group I mGluR agonist Dihydroxyphenylglycine (DHPG, 100 nM/5 μL, i.c.v.) in male Sprague-Dawley rats.

Animal Model:	Male Swiss mice (25-35 g)
Dosage:	3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.) and 1-10 nmol/ site (i.c.v.)
Administration:	Single injection
Result:	The maximal inhibition values for the antinociceptive action of E4CPG in glutamate-induced nociception were 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.).

Animal Model:	Male Sprague-Dawley rats
Dosage:	35 nM/3.5 μL
Administration:	Single injection, i.c.v.
Result:	Completely blocked LTD induced by the group I mGluR agonist dihydroxyphenylglycine (DHPG).

安全信息

MSDS信息

4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID 价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2025/12/22	HY-100372	4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID E4CPG	170846-89-6	5mg	600元
2025/12/22	HY-100372	4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID E4CPG	170846-89-6	10mg	800元

4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID