|
|
| | N-METHOXY-N-METHYLTRIFLUOROACETAMIDE Basic information |
| Product Name: | N-METHOXY-N-METHYLTRIFLUOROACETAMIDE | | Synonyms: | N-METHYL-N-METHOXYTRIFLUOROACETAMIDE;N-METHOXY-N-METHYLTRIFLUOROACETAMIDE;N-METHOXY-N-METHYL-2,2,2-TRIFLUOROACETAMIDE;N-Methoxy-N-methyltrifluoroacetamide 98%;N-Methoxy-N-methyltrifluoroacetamide98%;4-Methoxy-3-methylthiophenol;N-Methoxy-N-methyl-2,2,2-trifluoroacetamide 98%;N-Methoxy-N-(trifluoroacetyl)methylamine, N-Methoxy-N-methyl-2,2,2-trifluoroacetamide | | CAS: | 104863-67-4 | | MF: | C4H6F3NO2 | | MW: | 157.09 | | EINECS: | | | Product Categories: | | | Mol File: | 104863-67-4.mol |  |
| | N-METHOXY-N-METHYLTRIFLUOROACETAMIDE Chemical Properties |
| Boiling point | 53 °C/30 mmHg (lit.) | | density | 1.299 g/mL at 25 °C (lit.) | | refractive index | 1.3630 to 1.3670 | | Fp | 118 °F | | storage temp. | Sealed in dry,Room Temperature | | form | clear liquid | | color | Colorless to Light yellow | | InChI | InChI=1S/C4H6F3NO2/c1-8(10-2)3(9)4(5,6)7/h1-2H3 | | InChIKey | JDBJZZTZYKUFFK-UHFFFAOYSA-N | | SMILES | C(N(OC)C)(=O)C(F)(F)F | | CAS DataBase Reference | 104863-67-4(CAS DataBase Reference) |
| Hazard Codes | T,Xi | | Risk Statements | 10-25-36 | | Safety Statements | 16-26-45 | | RIDADR | UN 1992 3/PG 3 | | WGK Germany | 3 | | HazardClass | IRRITANT | | PackingGroup | III | | HS Code | 2924190090 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Acute Tox. 3 Oral
Eye Irrit. 2
Flam. Liq. 3 |
| | N-METHOXY-N-METHYLTRIFLUOROACETAMIDE Usage And Synthesis |
| Chemical Properties | Clear colorless liquid | | Synthesis | To a suspension of N,O-dimethylhydroxylamine hydrochloride (107.2 kg, 1.1 kmol) in dichloromethane (400 L) was sequentially added trifluoroacetic anhydride (210 kg, 1 kmol) and pyridine (174 kg, 2.2 kmol) at 0 °C. The reaction mixture was stirred continuously at 0 °C for 1 hour. Subsequently, the reaction solution was diluted with ice water (300 L) and washed with 2M hydrochloric acid (300 L). The aqueous phase was extracted twice with dichloromethane, the organic phases were combined and dried with anhydrous magnesium sulfate. After concentration of the organic phase, the crude N-methoxy-N-methyl-2,2,2-trifluoroacetamide (Weinreb amide) was obtained with 90% purity and 95% yield, which could be used in the subsequent reaction without further purification. | | References | [1] Asian Journal of Chemistry, 2015, vol. 27, # 7, p. 2406 - 2408
[2] Journal of Organic Chemistry, 1991, vol. 56, # 13, p. 4260 - 4263
[3] Journal of Medicinal Chemistry, 2006, vol. 49, # 26, p. 7887 - 7896
[4] Patent: WO2003/101932, 2003, A2. Location in patent: Page 64
[5] Patent: WO2003/82787, 2003, A1. Location in patent: Page/Page column 108 |
| | N-METHOXY-N-METHYLTRIFLUOROACETAMIDE Preparation Products And Raw materials |
|