|
|
| | 4-Hydroxy-3-methoxybenzylamine hydrochloride Basic information |
| | 4-Hydroxy-3-methoxybenzylamine hydrochloride Chemical Properties |
| Melting point | 219-221 °C (dec.)(lit.) | | storage temp. | Store below +30°C. | | solubility | DMSO (Slightly, Heated), Methanol (Slightly) | | form | Powder | | color | Off-white | | Sensitive | Moisture Sensitive | | BRN | 3915418 | | Stability: | Hygroscopic | | InChI | InChI=1S/C8H11NO2.ClH/c1-11-8-4-6(5-9)2-3-7(8)10;/h2-4,10H,5,9H2,1H3;1H | | InChIKey | PUDMGOSXPCMUJZ-UHFFFAOYSA-N | | SMILES | C1(OC)=C(O)C=CC(CN)=C1.Cl | | LogP | 5.4 at 30℃ | | CAS DataBase Reference | 7149-10-2(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39-36 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29214990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2 |
| | 4-Hydroxy-3-methoxybenzylamine hydrochloride Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powde | | Uses | A metabolite of Capsaicin. | | Synthesis | The preparation method of the present invention for the preparation of vanillin amine hydrochloride is described in detail in the following steps: A, 4-hydroxy-3-methoxybenzaldehyde oxime was used as raw material, and ethanol was used as solvent; firstly, 133.6 g (0.80 mol) of 4-hydroxy-3-methoxybenzaldehyde oxime was added into a 2L three-necked flask fitted with a stirrer and a thermometer, and then 1,400mL of ethanol and 13.0 g of an aluminum-zinc Nickel composite catalyst, under the condition of passing hydrogen for protection, heating to 40°C, the reaction for 8 hours; B, after the completion of the reaction filtration (the filtrate residue is the unreacted catalyst, can be recycled), in the filtrate add 70mL of hydrochloric acid with a mass concentration of 30%, adjusting the filtrate pH to 1, precipitated white crystals, filtration to isolate the white crystals, drying in vacuum, to obtain vanillin amine hydrochloride 136.8 g, yield 90.5%. | | References | [1] Polymer, 2011, vol. 52, # 9, p. 1908 - 1916
[2] Journal of Organic Chemistry, 1988, vol. 53, # 5, p. 1064 - 1071
[3] Patent: CN106366004, 2017, A. Location in patent: Paragraph 0017-0028
[4] Patent: JP2005/527478, 2005, A. Location in patent: Page/Page column 4
[5] Russian Chemical Bulletin, 2018, vol. 67, # 8, p. 1394 - 1400 |
| | 4-Hydroxy-3-methoxybenzylamine hydrochloride Preparation Products And Raw materials |
|