- Fenoldopam
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- $0.00 / 1Kg
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2020-05-10
- CAS:67227-56-9
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 500 MT
- Fenoldopam
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- $1.00 / 1KG
-
2019-07-06
- CAS:67227-56-9
- Min. Order: 1G
- Purity: 98%
- Supply Ability: 100KG
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| | Fenoldopam Basic information |
| | Fenoldopam Chemical Properties |
| Boiling point | 522.6±50.0 °C(Predicted) | | density | 1.380±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: >12 mg/mL | | form | Powder | | pka | 8.50±0.40(Predicted) | | color | off-white | | InChI | InChI=1S/C16H16ClNO3/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21/h1-4,7,13,18-21H,5-6,8H2 | | InChIKey | TVURRHSHRRELCG-UHFFFAOYSA-N | | SMILES | N1CCC2=C(Cl)C(O)=C(O)C=C2C(C2=CC=C(O)C=C2)C1 | | CAS DataBase Reference | 67227-56-9(CAS DataBase Reference) |
| | Fenoldopam Usage And Synthesis |
| Chemical Properties | Fenoldopam Hydrobromide: C16H16C1NO3/HBr. Melting point: 277°C (decomposition). Fenoldopam Mesylate: C16H16C1NO3/CH3SO3. [67227-57-0]. Melting point: 274°C (decomposition). | | Originator | Corlopam,Pharmaforce, Inc. | | Uses | Dopamine D1-receptor agonist. Antihypertensive. | | Uses | dopamine receptor agonists | | Uses | The dopamine receptors play important role in cognition, memory, learning, and motor control (1). These receptors have been implicated as a therapeutic target for many psychiatric and neurological disorders. Fenoldopam is a selective dopamine 1 receptor agonist with diuretic and properties (2,3). | | Definition | ChEBI: Fenoldopam is a benzazepine. It has a role as a dopaminergic antagonist, a vasodilator agent, an alpha-adrenergic agonist, a dopamine agonist and an antihypertensive agent. | | Manufacturing Process | 2-Chloro-3,4-dimethoxyphenethylamine (1.0 g) was reacted with 0.70 g of pmethoxystyrene
oxide to give the hydroxyphenethylamine; m.p. 118.5-121°C.
This compound (2.16 g) was stirred at room temperature in 15 ml of
trifluoroacetic acid with 4 drops of conc. sulfuric acid. After purification over a
silica gel column with chloroform, 10% methanol/chloroform as eluates, was
obtained 6-chloro-7,8-dimethoxy-1-p-methoxyphenyl-2,3,4,5-tetrahydro-1H-
3-benzazepine (0.78 g), m.p. 143-145°C.
The trimethoxy product (0.87 g, 2.50 mmoles) in 25 ml of dry methylene
chloride was cooled in an ice-methanol bath and 12.5 ml (25.0 mmoles) of
boron tribromide in methylene chloride was added dropwise. After stirring for
4 hours, the mixture was cooled in an ice bath while methanol was carefully
added to give 0.37 g of 6-chloro-7,8-dihydroxy-1-p-hydroxyphenyl-2,3,4,5-
tetrahydro-1H-3-benzazepine hydrobromide, m.p. 215°C.
The base was regenerated from the hydrobromide salt using sodium carbonate solution in 85% yield. Treating the base with various acids gave the
following salts: dl-tartrate, fumarate, hydrochloride, sulfate, and the most
water soluble one, the methanesulfonate, m.p. 272°C. | | Brand name | Corlopam (Hospira). | | Therapeutic Function | Antihypertensive | | Biological Activity | Selective D 1 -like dopamine receptor partial agonist (EC 50 = 57 nM). Vasodilator in vivo and does not readily cross the blood-brain barrier. Also α 2 -adrenoceptor antagonist in vitro (K i = 15-25 nM). |
| | Fenoldopam Preparation Products And Raw materials |
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