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| | N-[(Trimethylsilyl)methyl]benzylamine Basic information |
| | N-[(Trimethylsilyl)methyl]benzylamine Chemical Properties |
| Boiling point | 89-90 °C5 mm Hg(lit.) | | density | 0.88 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.496(lit.) | | Fp | 205 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 9.29±0.20(Predicted) | | form | Liquid | | color | Pale yellow | | Specific Gravity | 0.88 | | Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions | | InChI | InChI=1S/C11H19NSi/c1-13(2,3)10-12-9-11-7-5-4-6-8-11/h4-8,12H,9-10H2,1-3H3 | | InChIKey | WECLUYCAWLJMKM-UHFFFAOYSA-N | | SMILES | C1(CNC[Si](C)(C)C)=CC=CC=C1 | | CAS DataBase Reference | 53215-95-5(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | TSCA | No | | HS Code | 29319090 |
| | N-[(Trimethylsilyl)methyl]benzylamine Usage And Synthesis |
| Chemical Properties | Colorless liquid | | Uses | N-[(Trimethylsilyl)methyl]benzylamine may be used in chemical synthesis. | | General Description | N-[(Trimethylsilyl)methyl]benzylamine is useful intermediate to cyanoaminosilanes which are subsequently used as azomethine ylide equivalents. | | Synthesis | General method: Benzylamine derivatives (24.3 mmol, 37 (2.6 g); 28.0 mmol, 38 (3.4 g); 28.0 mmol, 39 (3.8 g); 11.2 mmol, 40 (1.4 g); and 11.2 mmol, 41 (2.0 g)) were dissolved in acetonitrile (120 mL), added K2CO3 (37.4 mmol, 5.2 g (for 37); 46.7 mmol, 2.5 g (for 38-39); 18.7 mmol, 2.6 g (for 40-41)) and Me3SiCH2I (18.5 mmol, 4.0 g (for 37); 38.4 mmol, 59 g (for 38-39); 9.3 mmol, 2.0 g (for 40-41)). The reaction mixture was stirred for 12 h at room temperature. After completion of the reaction, the mixture was concentrated in vacuum to give a residue. The residue was ground with CH2Cl2, dried and concentrated again under vacuum. Finally, it was purified by silica gel column chromatography (eluent ratio: EtOAc:hexane=1:8~1:15) to give the products 421 (3.2 g, 89%), 43 (3.85 g, 79%), 442 (3.3 g, 63%), 45 (1.51 g, 76%) and 46 (1.9 g, 78%), respectively. | | References | [1] Tetrahedron Letters, 2015, vol. 56, # 23, p. 3014 - 3018
[2] Organic and Biomolecular Chemistry, 2016, vol. 14, # 44, p. 10502 - 10510
[3] Tetrahedron Letters, 2017, vol. 58, # 10, p. 949 - 954
[4] Tetrahedron, 2017, vol. 73, # 44, p. 6249 - 6261 |
| | N-[(Trimethylsilyl)methyl]benzylamine Preparation Products And Raw materials |
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