- Smilagenin
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- $64.00 / 5mg
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2026-01-05
- CAS:126-18-1
- Min. Order:
- Purity: 98.00%
- Supply Ability: 10g
- Smilagenin
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- $0.00 / 25kg
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2025-12-01
- CAS:126-18-1
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1000kg
- (25R)-5β-spirostan-3β-ol
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- $15.00 / 1KG
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2021-07-02
- CAS:126-18-1
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | SMILAGENIN Basic information |
| Product Name: | SMILAGENIN | | Synonyms: | 5BETA,20ALPHA,22ALPHA,25D-SPIRANOSTAN-3BETA-OL;5-BETA, 20-ALPHA, 22-ALPHA, 25D-SPIROSTAN-3-BETA-OL;25R,5BETA-SPIROSTAN-3BETA-OL;(25R)-SPIROSTAN-3BETA-OL;16,22:22,26-BIS(EPOXY)CHOLESTAN-3BETA-OL;SMILAGENIN;(25r)-spirostan-3β-ol;(25R)-Spirostan-3β-ol, 16,22:22,26-Bis(epoxy)cholestan-3β-ol | | CAS: | 126-18-1 | | MF: | C27H44O3 | | MW: | 416.64 | | EINECS: | 204-775-8 | | Product Categories: | Steroids | | Mol File: | 126-18-1.mol |  |
| | SMILAGENIN Chemical Properties |
| Melting point | ~185 °C | | alpha | D25 -69° (c = 0.5 in chloroform) | | Boiling point | 474.91°C (rough estimate) | | density | 1.0362 (rough estimate) | | refractive index | 1.4700 (estimate) | | storage temp. | Store at -20°C | | solubility | Ethanol: ≥ 10 mg/mL (24.00 mM); DMSO: < 1 mg/mL (insoluble or slightly soluble) | | pka | 15.14±0.70(Predicted) | | form | Solid | | color | White to off-white |
| | SMILAGENIN Usage And Synthesis |
| Uses | Smilagenin (SMI) is a small-molecule steroidal sapogenin from Anemarrhena asphodeloides and Pelargonium hortorum widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases[1].
Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density[2].
Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD[3]. | | Definition | ChEBI: An oxaspiro compound that is(5beta,25R)-spirostan substituted by a beta-hydroxy group at position 3. | | in vivo | Smilagenin (intragastric administration; 10 or 26 mg/kg, once daily; 60 days) prevents the impairment of dopaminergic neurons in chronic MPTP/probenecid-induced mouse model[2]. | Animal Model: | MPTP/probenecid-induced mouse model[2] | | Dosage: | 10 or 26 mg/kg | | Administration: | Intragastric administration; 10 or 26 mg/kg; once daily; 60 days | | Result: | Ameliorated locomotor ability of MPTP/probenecid-lesioned mice. |
| | IC 50 | mAChR1 | | Purification Methods | Chromatograph smilagenin on active Al2O3 and elute with *C6H6, then recrystallise it from Me2CO, aqueous EtOH (m 187-188o) or MeOH. The acetate crystallises from MeOH with m 152o and [] D 25 -59.6o, [] 546 25 –68.9o (c 0.25, CHCl3). [Askew J Chem Soc 1399 1936 and 1402 1936, Scheer et al. J Am Chem Soc 77 6411955, Beilstein 19 III/IV 826.] | | References | [1] He X, et al. Smilagenin Protects Dopaminergic Neurons in Chronic MPTP/Probenecid-Lesioned Parkinson's Disease Models. Front Cell Neurosci. 2019 Feb 5;13:18. DOI:10.3389/fncel.2019.00018
[2] Hu Y, et al. Regulation of M1-receptor mRNA stability by smilagenin and its significance in improving memory of aged rats. Neurobiol Aging. 2010 Jun;31(6):1010-9. DOI:10.1016/j.neurobiolaging.2008.06.008
[3] Zhang R, et al. Smilagenin attenuates beta amyloid (25-35)-induced degeneration of neuronal cells via stimulating the gene expression of brain-derived neurotrophic factor. Neuroscience. 2012 May 17;210:275-85 DOI:10.1016/j.neuroscience.2012.03.017 |
| | SMILAGENIN Preparation Products And Raw materials |
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