- 3-Amino-5-fluoropyridine
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- $0.00 / 1kg
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2025-12-29
- CAS:210169-05-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: follow your request
- 3-AMINO-5-FLUOROPYRIDINE
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- $1.10 / 1g
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2025-06-25
- CAS:210169-05-4
- Min. Order: 1g
- Purity: 99.0% min
- Supply Ability: 100 tons min
- 5-fluoropyridin-3-amine
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- $0.00 / 1KG
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2022-02-19
- CAS:210169-05-4
- Min. Order: 1KG
- Purity: 98.7%
- Supply Ability: 100 tons
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| | 3-Amino-5-fluoropyridine Basic information |
| | 3-Amino-5-fluoropyridine Chemical Properties |
| Melting point | 86°C | | Boiling point | 232.7±20.0 °C(Predicted) | | density | 1.257±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | powder to crystal | | pka | 3.74±0.20(Predicted) | | color | Light orange to Yellow to Green | | InChI | InChI=1S/C5H5FN2/c6-4-1-5(7)3-8-2-4/h1-3H,7H2 | | InChIKey | ZRORIJXOWXYPMO-UHFFFAOYSA-N | | SMILES | C1=NC=C(F)C=C1N | | CAS DataBase Reference | 210169-05-4(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 20/21/22-36/37/38-22 | | Safety Statements | 26-36-36/37 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 2933399990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 3-Amino-5-fluoropyridine Usage And Synthesis |
| Chemical Properties | Light yellow Crystal | | Uses | 3-amino-5-fluoropyridine is an important intermediate mainly used in medicine and organic synthesis. It is used to synthesize Ivosidenib. Ivosidenib is an isocitrate dehydrogenase-1 inhibitor used to treat acute myeloid leukemia and cholangiocarcinoma in adults. | | Application | Reactant for:
Preparation of nonpeptide inhibitors of measles virus entry. | | Preparation | synthesis of 3-Amino-5-fluoropyridine: A solution of 3-amino-2,4,6-tribromo-5-fluoropyridine (23c) (0.9 g, 2.6 mmol), triethylamine (1.1 cm3, 7.9 mmol), palladium catalyst (0.1 g of 5% Pd-C catalyst) and DCM (15 cm3) was hydrogenated on a Parr apparatus for 18 h. Water (20 cm3) was added and the mixture filtered and extracted into DCM. The DCM solution was dried (MgS04) and evaporated giving 3-amino-5-fluoropyridine (0.3 g, >95% ), m.p. 86 ·c (from DCM) (Found: C, 53.6; H, 4.6; N, 25.0. C5H5FN2 requires C, 53.6; H, 4.5 N, 25.0%);
IR spectrum no. 9; mass spectrum no. 5; nmr spectrum no. 29. |
| | 3-Amino-5-fluoropyridine Preparation Products And Raw materials |
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