- Z-GLN(TRT)-OH
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- $1.00 / 1KG
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2019-07-06
- CAS:132388-60-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20kg
- Z-GLN(TRT)-OH
-
- $7.00 / 1KG
-
2019-07-06
- CAS:132388-60-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100KG
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| | Z-GLN(TRT)-OH Basic information |
| | Z-GLN(TRT)-OH Chemical Properties |
| Boiling point | 792.6±60.0 °C(Predicted) | | density | 1.237±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Solid | | pka | 3.82±0.10(Predicted) | | Appearance | White to off-white Solid | | CAS DataBase Reference | 132388-60-4(CAS DataBase Reference) |
| | Z-GLN(TRT)-OH Usage And Synthesis |
| Chemical Properties | White powder | | Synthesis | Acetic anhydride (7.50 mL, 80.00 mmol) and concentrated sulfuric acid were added to glacial acetic acid (120 mL) as (S)-5-amino-2-(((benzyloxy)carbonyl)amino)-5-oxopentanoic acid (11.20 g, 40.00 mmol) and triphenylmethanol (20.80 g, 80.00 mmol). The mixture was stirred in an ice bath and then gradually warmed up to 50 °C for 2 hours of reaction. Upon completion of the reaction, the reaction mixture was slowly poured into ice (800 g) and a white precipitate precipitated. The precipitate was collected by filtration and redissolved in ethyl acetate (600 mL). The resulting solution was washed sequentially with water (3 x 200 mL), dried over anhydrous sodium sulfate, filtered and concentrated. Finally, the white solid N-Cbz-N'-trityl-L-glutamine (14.70 g, 70% yield) was obtained by solvent crystallization from ethyl acetate/petroleum ether mixture. | | References | [1] Journal of the American Chemical Society, 2013, vol. 135, # 35, p. 12998 - 13007
[2] Journal of Peptide Science, 2010, vol. 16, # 7, p. 364 - 374
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 15, p. 2786 - 2805
[4] Synthetic Communications, 2017, vol. 47, # 12, p. 1136 - 1141
[5] Tetrahedron Letters, 1991, vol. 32, # 6, p. 739 - 742 |
| | Z-GLN(TRT)-OH Preparation Products And Raw materials |
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