| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
18210857532; 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Dihydrexidine
CAS:123039-93-0
Package:100Mg,10Mg,1Mg
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
|
| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:Dihydrexidine hydrochloride;(±)-trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridinehydrochloride
CAS:123039-93-0
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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DIHYDREXIDINE HYDROCHLORIDE manufacturers
- Dihydrexidine
-
- $2580.00 / 50mg
-
2026-01-05
- CAS:123039-93-0
- Min. Order:
- Purity:
- Supply Ability: 10g
- Dihydrexidine
-
- $2580.00 / 50mg
-
2025-07-20
- CAS:123039-93-0
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | DIHYDREXIDINE HYDROCHLORIDE Basic information |
| Product Name: | DIHYDREXIDINE HYDROCHLORIDE | | Synonyms: | DIHYDREXIDINE HYDROCHLORIDE;(+/-)-TRANS-10,11-DIHYDROXY-5,6,6A,7,8,12B-HEXAHYDROBENZO[A]PHENANTHRIDINE HYDROCHLORIDE;DihydrexidineHCl;DIHYDROXIDINE HYDROCHLORIDE;DAR-0100;Benzo[a]phenanthridine-10,11-diol, 5,6,6a,7,8,12b-hexahydro-, (6aR,12bS)-rel-;Dihydrexidine hydroc | | CAS: | 123039-93-0 | | MF: | C17H17NO2 | | MW: | 267.32 | | EINECS: | | | Product Categories: | Dopamine receptor | | Mol File: | 123039-93-0.mol |  |
| | DIHYDREXIDINE HYDROCHLORIDE Chemical Properties |
| Boiling point | 488.270±45.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.267±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO | | form | solid | | pka | 10.046±0.20(predicted) |
| | DIHYDREXIDINE HYDROCHLORIDE Usage And Synthesis |
| Uses | Dihydrexidine is a moderately selective full agonist at the dopamine D1 and D5 receptors (1,2). It has been shown to have antiparkinson effects. It also has the ability to improving the cognitive and working memory deficits in schizophrenia and schizotypal disorder. | | Biological Activity | A potent, full efficacy dopamine D 1 agonist which shows no agonist activity at peripheral D 2 receptors or adrenoceptors at doses which cause maximal stimulation of D 1 sites. The compound appears to be fully bioavailable in brain and exhibits profound antiparkinsonism effects in vivo . | | in vivo | Dihydrexidine has poor oral bioavailability and a relatively short half-life of 1 to 2 h[3].
Dihydrexidine (3 mg/kg; i.p.) produces prominent dopamine D1 receptor agonist effects in vivo[4].
| Animal Model: | Adult male Sprague–Dawley rats (275-300 g)[4] | | Dosage: | Adult male Sprague–Dawley rats (275-300 g)[4] | | Administration: | Intraperitoneal injection | | Result: | Produces prominent dopamine D1 receptor agonist effects in vivo |
| | IC 50 | D1 Receptor: 10 nM (IC50) |
| | DIHYDREXIDINE HYDROCHLORIDE Preparation Products And Raw materials |
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