|
|
| | Difenidol hydrochloride Basic information |
| Product Name: | Difenidol hydrochloride | | Synonyms: | DIFENIDOL HYDROCHLORIDE;DIPHENIDOL;DIPHENIDOL HYDROCHLORIDE;LABOTEST-BB LT00771934;1,1-DIPHENYL-4-PIPERIDINO-1-BUTANOL HYDROCHLORIDE;1,1-diphenyl-4-(1-piperidyl)butan-1-ol hydrochloride;1-(4-HYDROXY-4,4-DIPHENYLBUTYL)PIPERIDINE HYDROCHLORIDE;alpha,alpha-diphenyl-1-piperidinebutanohydrochloride | | CAS: | 3254-89-5 | | MF: | C21H27NO | | MW: | 309.45 | | EINECS: | 221-850-0 | | Product Categories: | | | Mol File: | 3254-89-5.mol |  |
| | Difenidol hydrochloride Chemical Properties |
| Melting point | 212-214° | | storage temp. | 2-8°C | | solubility | DMSO (Slightly, Sonicated), Methanol (Slightly) | | form | Solid | | color | White to Off-White | | PH | pH (10g/l, 25℃) : 4.7～6.5 | | Water Solubility | H2O: 2mg/mL, clear (warmed) | | Merck | 14,3311 | | InChI | InChI=1S/C21H27NO/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22/h1-2,4-7,11-14,23H,3,8-10,15-18H2 | | InChIKey | OGAKLTJNUQRZJU-UHFFFAOYSA-N | | SMILES | C(O)(CCCN1CCCCC1)(C1=CC=CC=C1)C1C=CC=CC=1 | | CAS DataBase Reference | 3254-89-5(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 20/21/22 | | Safety Statements | 36 | | WGK Germany | 3 | | RTECS | TM4970500 | | HS Code | 2933.39.9200 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral | | Toxicity | LD50 oral in rat: 515mg/kg |
| | Difenidol hydrochloride Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | Diphenidol is an muscarinic antagonist is an antivertigo agent. Diphenidol displays heart arrhythmia inhibition and parasympatholytic activity. | | Definition | ChEBI: Difenidol hydrochloride is a diarylmethane. | | Brand name | Vontrol (GlaxoSmithKline). | | Biological Activity | Diphenidol is a non-selective muscarinic acetylcholine receptor antagonist. Diphenidol is an antiemetic agent used in the treatment of vomiting and vertigo. | | Synthesis | Difenidol hydrochloride is synthesized in three steps. S1: Preparation of 1-(3-chloropropyl)hexahydropyridine: 1,3-Bromochloropropane reacts with hexahydropyridine at room temperature. Liquid base is then added. After layering, the oily layer is collected and dried to give the intermediate. S2: Preparation of ??,??-diphenyl-1-piperidinobutanol: After initiation with magnesium, a THF solution of intermediate N-(3-chloropropyl)piperidine is added dropwise, followed by a THF solution of benzophenone. After holding, the mixture is poured into ice-cold ammonium chloride solution for hydrolysis. Filtration and drying yield the product. S3: Preparation of ??,??-diphenyl-1-piperidinobutanol hydrochloride: The product from step 2 is dissolved in acetone. After decolorization, hydrochloric acid is added dropwise to form the salt. Gradient cooling induces crystallization. Filtration and drying give the final product. |
| | Difenidol hydrochloride Preparation Products And Raw materials |
|