|
|
| | ORPHENADRINE HYDROCHLORIDE Basic information |
| Product Name: | ORPHENADRINE HYDROCHLORIDE | | Synonyms: | 2-Dimethylaminoethyl 2-methylbenzhydryl ether hydrochloride;Ethanamine, N,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]-, hydrochloride;Ethylamine, N,N-dimethyl-2-((o-methyl-alpha-phenylbenzyl)oxy)-, hydrochloride;Ethylamine, N,N-dimethyl-2-(alpha-(o-tolyl)benzyloxy)-, hydrochloride;Ethylamine, N,N-dimethyl-2-(phenyl-(o-tolyl)methoxy)-, hydrochloride;Mebedrol;Mefenamin hydrochloride;Mephenamin | | CAS: | 341-69-5 | | MF: | C18H24ClNO | | MW: | 305.84 | | EINECS: | 206-435-4 | | Product Categories: | API | | Mol File: | 341-69-5.mol |  |
| | ORPHENADRINE HYDROCHLORIDE Chemical Properties |
| Melting point | 159.0 to 164.0 °C | | Boiling point | -195 °C | | density | 0.295 g/cm3 | | storage temp. | 2-8°C | | solubility | Freely soluble in water and in ethanol (96 per cent). | | form | powder | | color | Crystals | | BRN | 3745818 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | Major Application | pharmaceutical (small molecule) | | InChI | 1S/C18H23NO.ClH/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16;/h4-12,18H,13-14H2,1-3H3;1H | | InChIKey | UQZKYYIKWZOKKD-UHFFFAOYSA-N | | SMILES | Cl.CN(C)CCOC(c1ccccc1)c2ccccc2C | | CAS DataBase Reference | 341-69-5(CAS DataBase Reference) | | EPA Substance Registry System | Orphenadrine hydrochloride (341-69-5) |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 36 | | RIDADR | 3249 | | WGK Germany | 3 | | RTECS | KR6300000 | | HazardClass | 6.1(b) | | PackingGroup | III | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral | | Toxicity | LD50 oral in rat: 255mg/kg |
| | ORPHENADRINE HYDROCHLORIDE Usage And Synthesis |
| Chemical Properties | White or almost white, crystalline powder. | | Uses | Antihistaminic;H1 antogonist | | Definition | ChEBI: A hydrochloride comprising equimolar amounts of ophenadrine and hydrogen chloride. | | General Description | Odorless white or almost white crystalline powder. pH (aqueous solution) about 5.5. Bitter numbing taste. | | Air & Water Reactions | May be sensitive to prolonged exposure to light and air. Water soluble. | | Reactivity Profile | ORPHENADRINE HYDROCHLORIDE is incompatible with strong oxidizers. | | Fire Hazard | Flash point data for ORPHENADRINE HYDROCHLORIDE are not available; however, ORPHENADRINE HYDROCHLORIDE is probably combustible. | | Biochem/physiol Actions | Muscarinic receptor antagonist; H1 histamine receptor antagonist; muscle relaxant. Orphenadrine has also been reported to inhibit the noradrenergic transporter and to block the NMDA receptor ion channel. | | Clinical Use | Anti-muscarinic:
Parkinsonism
Drug induced extra-pyramidal symptoms | | Safety Profile | Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects: mydriasis @updlaryd ilation), hallucinations, distorted perceptions, pulse rate increase, intracranial pressure increase. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl | | Metabolism | Orphenadrine is almost completely metabolised to at least
8 metabolites in the liver.
It is mainly excreted in the urine as metabolites and small
amounts of unchanged drug |
| | ORPHENADRINE HYDROCHLORIDE Preparation Products And Raw materials |
|