Cholesteryl sodium sulfate manufacturers
|
| | Cholesteryl sodium sulfate Basic information |
| | Cholesteryl sodium sulfate Chemical Properties |
| Melting point | 178-180°C | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | Methanol (Slightly, Heated) | | form | White to off-white powder. | | color | White to Off-White | | biological source | synthetic | | BRN | 3899884 | | Cosmetics Ingredients Functions | SKIN CONDITIONING | | InChIKey | ZKMOLHRAYRDKHW-SMRZMENRNA-N | | SMILES | C[C@]12CC[C@H](OS(O)(=O)=O)CC1=CC[C@@]1([H])[C@]3([H])CC[C@]([H])([C@H](C)CCCC(C)C)[C@@]3(C)CC[C@]21[H].[NaH] |&1:1,4,14,16,20,22,30,34,r| | | CAS DataBase Reference | 2864-50-8(CAS DataBase Reference) |
| WGK Germany | 3 | | F | 3-10 | | Storage Class | 11 - Combustible Solids |
| | Cholesteryl sodium sulfate Usage And Synthesis |
| Description | Cholesterol sulfate is an endogenous component of cell membranes where it serves as a substrate for steroid synthesis, influences lipid metabolism, stabilizes cell membranes, regulates the activity of functional proteins, and plays a role in keratinocyte differentiation and development of the epidermal barrier. This synthetic formulation can be used to form nonconventional liposomes in order to study cellular membrane properties. | | Chemical Properties | White to Off-White Solid | | Uses | Principal sterol of the higher animals. Found in all body tissues, especial in the brain, spinal cord, and in animal fats or oils. Main constituent of gallstones. | | in vivo | Cholesteryl sulfate sodium (0.004% diet; oral; once daily, 6 days) antagonizes acute ulcerative colitis induced by DSS (HY-116282C) in male C57BL/6J mice, prevents weight loss, colon shortening and tissue damage, and reverses the exacerbated symptoms in Sult2b1△IEC mice[2].
Cholesteryl sulfate sodium (0.004% diet; oral; once daily, 33 days) improves survival and reduces inflammation in male C57BL/6J mice with chronic colitis induced by DSS[2].
Cholesteryl sulfate sodium (0.004% diet; oral; once daily, 42 days) alleviates spontaneous colitis caused by IL-10 deficiency in female IL-10-/- mice and reduces body weight loss and tissue damage[2].
Cholesteryl sulfate sodium (SCS) can synergize with Mitoxantrone hydrochloride (HY-13502A) to exert antitumor activity through a nano-delivery system[3].
| | References | [1] CHARLES A STROTT Yuko H. Cholesterol sulfate in human physiology: what’s it all about[J]. Journal of Lipid Research, 2003, 44 7: 1268-1278. DOI: 10.1194/jlr.r300005-jlr200 |
| | Cholesteryl sodium sulfate Preparation Products And Raw materials |
|