EGFR-IN-1

Request For Quotation
EGFR-IN-1 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:EGFR-IN-1
CAS:1625677-63-5
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:EGFR-IN-1
CAS:1625677-63-5
Package:50mg;2380USD|25mg;1820USD|100mg;3100USD
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:EGFR-IN-1
CAS:1625677-63-5
Package:50mg;2380USD|25mg;1820USD|100mg;3100USD
Company Name: cjbscvictory  
Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Products Intro: Product Name:EGFR-IN-1
CAS:1625677-63-5
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:EGFR-IN-1
CAS:1625677-63-5
Package:1removed

EGFR-IN-1 manufacturers

  • EGFR-IN-1
  • EGFR-IN-1 pictures
  • $2380.00 / 50mg
  • 2026-04-20
  • CAS:1625677-63-5
  • Min. Order:
  • Purity:
  • Supply Ability: 10g
  • EGFR-IN-1
  • EGFR-IN-1 pictures
  • $2380.00 / 50mg
  • 2025-08-22
  • CAS:1625677-63-5
  • Min. Order:
  • Purity:
  • Supply Ability: 10g
EGFR-IN-1 Basic information
Product Name:EGFR-IN-1
Synonyms:EGFR-IN-1;EGFR IN 1,EGFRIN1;2-Propenamide, N-[3-[2-[[4-[2-(dimethylamino)ethoxy]-2-methoxyphenyl]amino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl]phenyl]-
CAS:1625677-63-5
MF:C28H30N6O4
MW:514.58
EINECS:
Product Categories:
Mol File:1625677-63-5.mol
EGFR-IN-1 Structure
EGFR-IN-1 Chemical Properties
density 1.282±0.06 g/cm3(Predicted)
pka13.18±0.70(Predicted)
Safety Information
MSDS Information
EGFR-IN-1 Usage And Synthesis
UsesEGFR-IN-1 (compound 24) is an orally active and irreversible L858R/T790M mutant selective EGFR inhibitor. EGFR-IN-1 potently inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 displays strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. Antitumor activity[1].
in vivo

EGFR-IN-1 (30 mg/kg; p.o.; daily for 2 weeks) displays significant tumor growth inhibition with no observed loss in body weight[1].
EGFR-IN-1 evaluates in a time course PD experiment upon oral dosing at 30 mg/kg. EGFR-IN-1 shows a >50% inhibition of phosphorylation of EGFR for >12 h. EGFR-IN-1 reaches maximal concentration of 0.10 μM at 2 h and systemic exposure (AUC0-inf.) is 0.33 μM. h[1].

Animal Model:Female athymic nude mice (H1975 Tumor Xenograft)[1]
Dosage:30 mg/kg
Administration:p.o.; daily for 2 weeks
Result:Led to significant tumor growth inhibition with no observed loss in body weight.
IC 50EGFRL858R/T790M
References[1] Wurz RP, et al. Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors. ACS Med Chem Lett. 2015 Jul 27;6(9):987-92. DOI:10.1021/acsmedchemlett.5b00193
EGFR-IN-1 Preparation Products And Raw materials
Tag:EGFR-IN-1(1625677-63-5) Related Product Information