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| | m-PEG12-NH-C2-acid Basic information |
| Product Name: | m-PEG12-NH-C2-acid | | Synonyms: | m-PEG12-NH-C2-acid;m-PEG12-CH2CH2NHCH2CH2COOH;3-{[2-(2-methoxyethoxy)ethyl]amino}propanoic acid;Poly(oxy-1,2-ethanediyl), α-[2-[(2-carboxyethyl)amino]ethyl]-ω-methoxy- | | CAS: | 1949843-39-3 | | MF: | (C2H4O)nC6H13NO3 | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | 1949843-39-3.mol |  |
| | m-PEG12-NH-C2-acid Chemical Properties |
| | m-PEG12-NH-C2-acid Usage And Synthesis |
| Description | m-PEG12-CH2CH2NHCH2CH2COOH is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. | | Uses | m-PEG12-NH-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | m-PEG12-NH-C2-acid Preparation Products And Raw materials |
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