Alkyne tyramide
| 中文名称 | Alkyne tyramide |
|---|---|
| 中文同义词 | 化合物ALKYNE TYRAMIDE;N-(4-羟基苯乙基)戊-4-炔酰胺;化合物ALKYNE TYRAMIDE,10 MM DMSO 溶液;Alkyne tyramide 试剂;Alkyne tyramide 试剂;炔烃酪酰胺 |
| 英文名称 | Alkyne tyramide |
| 英文同义词 | Alkyne tyramide;Alkyne tyramide,membrane,mitochondria,topology,Inhibitor,inhibit,APEX2,substrate,yeast;4-Pentynamide, N-[2-(4-hydroxyphenyl)ethyl]-;Alkyne-phenol;Alkyne tyramide, 10 mM in DMSO;N-(4-Hydroxyphenethyl)pent-4-ynamide |
| CAS号 | 1694495-59-4 |
| 分子式 | C13H15NO2 |
| 分子量 | 217.26 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1694495-59-4.mol |
| 结构式 |  |
Alkyne tyramide 性质
| 沸点 | 464.5±35.0 °C(Predicted) |
|---|---|
| 密度 | 1.126±0.06 g/cm3(Predicted) |
| 形态 | 固体 |
| 酸度系数(pKa) | 10.01±0.15(Predicted) |
| 颜色 | 白色至米白色 |
Alkyne tyramide 是一种抗坏血酸过氧化物酶 2 (APEX2) 探针。Alkyne tyramide 显著提高了完整酵母细胞的 APEX 标记效率，比 APEX2 底物生物素苯酚 (BP) 具有更大的细胞壁渗透性。Alkyne tyramide 还有助于鉴定 APEX 标记位点，明确线粒体蛋白的膜拓扑的分配。
Yeast cells expressing Su9-APEX2 are incubated with each probe at 2.5 mM final concentration for half an hour, and the labeling reaction is initiated by the addition of 1 mM H2O2. Alkyne tyramide is the most reactive APEX2 substrate for labeling the yeast proteome.
APEX2-mediated Alkyne tyramide labeling in the yeast mitochondria is more effective at probe concentrations above 1 mM.
Alkyne tyramide enables proteomic profiling in the mitochondrial matrix of intact yeast cells with exceptionally high specificity (94%), and offers higher coverage than the traditional APEX2 substrate biotin-phenol (BP).
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-131442 | Alkyne tyramide Alkyne-phenol | 1694495-59-4 | 5 mg | 333元 |
| 2025/12/22 | HY-131442 | Alkyne-phenol | 1694495-59-4 | 10 mg | 500元 |