| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
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| Tel: |
021-61312847; 18021002903 |
| Email: |
3008007409@qq.com |
| Products Intro: |
Product Name:Befovacimab (anti-TFPI)
CAS:2156634-62-5
Package:5mg;10mg Remarks:K30941
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| Company Name: |
ShangHai Biochempartner Co.,Ltd
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| Tel: |
177-54423994 17754423994 |
| Email: |
2853530910@QQ.com |
| Products Intro: |
Product Name:Befovacimab
CAS:2156634-62-5
Purity:95% Package:100ug;500ug;1mg
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| Company Name: |
Guangzhou Hongyuan Chemical Co.,Ltd
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| Tel: |
15817493340 |
| Email: |
981810490@qq.com |
| Products Intro: |
Product Name:Befovacimab
CAS:2156634-62-5
Purity:95% Package:1mg;1g;100g
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| Company Name: |
Biolab Reagents
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| Tel: |
027-65279366 18108604356 |
| Email: |
products@biolabreagent.com |
| Products Intro: |
Product Name:Research Grade Befovacimab (DHC82801)
CAS:2156634-62-5
Purity:PAGE:>95% Package:100ug;1mg
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| | Befovacimab Basic information |
| Product Name: | Befovacimab | | Synonyms: | Befovacimab;Research Grade Befovacimab (DHC82801);Research Grade Befovacimab | | CAS: | 2156634-62-5 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Befovacimab Structure]() |
| | Befovacimab Chemical Properties |
| | Befovacimab Usage And Synthesis |
| Uses | Befovacimab (BAY 1093884) is a fully human monoclonal IgG2 antibody able to bind to tissue factor pathway inhibitor (TFPI). Befovacimab can be used for haemophilia A/B research[1]. | | in vivo | In monkey plasma, Befovacimab exhibits an IC50 of 4.65 nM and 6.19 nM for free TFPI and diluted prothrombin time (dPT), respectively[1].
Befovacimab (5 and 20 mg/kg; intravenous and subcutaneous administration) dose‐dependent decreases in TFPI concentration and clotting time in female cynomolgus monkeys in vivo[1]. | | References | [1] Maria Elisa Mancuso, et al. Befovacimab, an anti-tissue factor pathway inhibitor antibody: Early termination of the multiple-dose, dose-escalating Phase 2 study due to thrombosis. Haemophilia. 2022 Sep;28(5):702-712. DOI:10.1111/hae.14595
[2] Jian-Ming Gu, et al. Mechanistic Modeling of the Pharmacodynamic and Pharmacokinetic Relationship of Tissue Factor Pathway Inhibitor-Neutralizing Antibody (BAY 1093884) in Cynomolgus Monkeys. AAPS J. 2017 Jul;19(4):1186-1195. DOI:10.1208/s12248-017-0086-4 |
| | Befovacimab Preparation Products And Raw materials |
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