Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-fluoro-, 6-[(1S)-1-[[[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]carbonyl]oxy]ethyl] ester, (1S,2S,3S,5R,6S)-

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Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-fluoro-, 6-[(1S)-1-[[[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]carbonyl]oxy]ethyl] ester, (1S,2S,3S,5R,6S)- Basic information
Product Name:Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-fluoro-, 6-[(1S)-1-[[[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]carbonyl]oxy]ethyl] ester, (1S,2S,3S,5R,6S)-
Synonyms:Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-fluoro-, 6-[(1S)-1-[[[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]carbonyl]oxy]ethyl] ester, (1S,2S,3S,5R,6S)-;MGS0274
CAS:1501974-69-1
MF:C21 H32 F N O7
MW:429.48
EINECS:
Product Categories:
Mol File:1501974-69-1.mol
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-fluoro-, 6-[(1S)-1-[[[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]carbonyl]oxy]ethyl] ester, (1S,2S,3S,5R,6S)- Structure
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-fluoro-, 6-[(1S)-1-[[[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]carbonyl]oxy]ethyl] ester, (1S,2S,3S,5R,6S)- Chemical Properties
Safety Information
MSDS Information
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-fluoro-, 6-[(1S)-1-[[[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]carbonyl]oxy]ethyl] ester, (1S,2S,3S,5R,6S)- Usage And Synthesis
DescriptionMGS0274 besylate is a prodrug of a potent group II metabotropic glutamate receptor agonist MGS0008 for the treatment of schizophrenia.
UsesMGS0274, an ester-based lipophilic proagent of a metabotropic glutamate (mGlu)2 and mGlu3 receptor agonist MGS0008, shows improved oral bioavailability. MGS0274 has the potential for the research of schizophrenia[1][2].
IC 50mGluR2; mGluR3
References[1] Urabe H, et al. Discovery of MGS0274, an ester prodrug of a metabotropic glutamate receptor 2/3 agonist with improved oral bioavailability [published online ahead of print, 2020 Jul 5]. Eur J Med Chem. 2020;203:112521. DOI:10.1016/j.ejmech.2020.112521
[2] Kinoshita K, et al. Preclinical disposition of MGS0274 besylate, a prodrug of a potent group II metabotropic glutamate receptor agonist MGS0008 for the treatment of schizophrenia. Pharmacol Res Perspect. 2019;7(5):e00520. Published 2019 Sep 13. DOI:10.1002/prp2.520
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-fluoro-, 6-[(1S)-1-[[[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]carbonyl]oxy]ethyl] ester, (1S,2S,3S,5R,6S)- Preparation Products And Raw materials
Tag:Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-fluoro-, 6-[(1S)-1-[[[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]carbonyl]oxy]ethyl] ester, (1S,2S,3S,5R,6S)-(1501974-69-1) Related Product Information
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