1H-Isoindole-1,3(2H)-dione, 4-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-

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1H-Isoindole-1,3(2H)-dione, 4-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)- Basic information
Product Name:1H-Isoindole-1,3(2H)-dione, 4-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-
Synonyms:1H-Isoindole-1,3(2H)-dione, 4-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-;4-Fluoro-2-(1-methyl-2,6-dioxopiperidin3-yl)isoindoline-1,3-dione;4-fluoro-2-(1-methyl-2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;4-fluoro-2-(1-methyl-2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione;N-Me-Thalidomide 4-fluoride
CAS:2244520-92-9
MF:C14H11FN2O4
MW:290.25
EINECS:
Product Categories:
Mol File:2244520-92-9.mol
1H-Isoindole-1,3(2H)-dione, 4-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)- Structure
1H-Isoindole-1,3(2H)-dione, 4-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)- Chemical Properties
Boiling point 487.4±40.0 °C(Predicted)
density 1.520±0.06 g/cm3(Predicted)
pka-2.61±0.40(Predicted)
form Solid
color Off-white to gray
Safety Information
MSDS Information
1H-Isoindole-1,3(2H)-dione, 4-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)- Usage And Synthesis
UsesN-Me-Thalidomide 4-fluoride is a ligand for E3 ligase, used for the synthesis of Anti-inflammatory agent 70 (HY-157570)[1].
IC 50Cereblon
References[1] Liu J, et al. Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy. J Med Chem. 2022 May 12;65(9):6593-6611. DOI:10.1021/acs.jmedchem.1c01948
1H-Isoindole-1,3(2H)-dione, 4-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)- Preparation Products And Raw materials
Tag:1H-Isoindole-1,3(2H)-dione, 4-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-(2244520-92-9) Related Product Information
5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione 1H-Isoindole-1,3(2H)-dione, 2-[(3R)-2,6-dioxo-3-piperidinyl]-4-fluoro- 1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-4-fluoro- 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4,5-difluoro- 1H-Isoindole-1,3(2H)-dione, 5,6-difluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-