UK 59811 hydrochloride

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Company Name: Sigma-Aldrich  
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Company Name: Shanghai Hongye Biotechnology Co. Ltd  
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Company Name: TargetMol Chemicals Inc.  
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UK 59811 hydrochloride Basic information
Product Name:UK 59811 hydrochloride
Synonyms:UK 59811 hydrochloride
CAS:2250025-89-7
MF:C22H30BrClN2O5
MW:517.85
EINECS:
Product Categories:
Mol File:2250025-89-7.mol
UK 59811 hydrochloride Structure
UK 59811 hydrochloride Chemical Properties
solubility Soluble to 20 mM in water and to 100 mM in DMSO
Safety Information
MSDS Information
UK 59811 hydrochloride Usage And Synthesis
UsesUK-59811 hydrochloride, a Br-dihydropyridine derivative, is a potent bacterial homotetrameric model voltage-gated Ca2+ (CaV) channel CaVAb inhibitor with an IC50 of 194 nM[1].
Biological ActivityUK 59811 hydrochloride is a blocks CaVAb, a site-directed mutant of bacterial NaVAb with full voltage-dependent Ca2+ channel function (IC50 = 194 nM).
storageStore at +4°C
References[1] Lin Tang, et al. Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs. Nature. 2016 Sep 1;537(7618):117-121. DOI:10.1038/nature19102
UK 59811 hydrochloride Preparation Products And Raw materials
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