Ethanone, 1-(5-hydroxybenzo[b]thien-2-yl)-

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Ethanone, 1-(5-hydroxybenzo[b]thien-2-yl)- Basic information
Product Name:Ethanone, 1-(5-hydroxybenzo[b]thien-2-yl)-
Synonyms:Ethanone, 1-(5-hydroxybenzo[b]thien-2-yl)-;1-(5-hydroxybenzo[b]thiophen-2-yl)ethanone;Dual DYRK/CLK inhibitor, Cpd 23
CAS:56363-81-6
MF:C10H8O2S
MW:192.23
EINECS:
Product Categories:
Mol File:56363-81-6.mol
Ethanone, 1-(5-hydroxybenzo[b]thien-2-yl)- Structure
Ethanone, 1-(5-hydroxybenzo[b]thien-2-yl)- Chemical Properties
Melting point 190-191 °C(Solv: chloroform (67-66-3))
Boiling point 375.4±22.0 °C(Predicted)
density 1.344±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: 50mg/mL
form powder
pka9.03±0.40(Predicted)
color yellow
SMILESO=C(C)C1=CC2=CC(O)=CC=C2S1
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
Ethanone, 1-(5-hydroxybenzo[b]thien-2-yl)- Usage And Synthesis
UsesA cell permeable 5-hydroxybenzothiophenylethanone that acts as a dual inhibitor of Cdc2-like kinase 1 (Clk1; IC50 = 60 nM) and dual specificity tyrosine phosphorylation-regulated kinases 1A/1B (Dyrk1A/1B; IC50 = 200 and 100 nM, respectively). Also inhibits Clk4 with high potency. Exhibits much reduced inhibitory effect on Haspin ( IC50 = 800 nM) and has much reduced inhibitory effect on other kinases even at higher concentration (~ 5 µM). Causes a complete disappearance of incomplete and alternatively spliced transcripts and is shown to enhance the generation of the mature Clk1 mRNA splicing product (EC50 = 8.9 µM) in cells.
A cell permeable, dual inhibitor of Cdc2-like kinase 1 (Clk1; IC₅₀ = 60 nM) and dual specificity tyrosine phosphorylation-regulated kinases 1A/1B (Dyrk1A/1B; IC₅₀ = 200 and 100 nM, respectively).
Biological ActivityCell permeable: yes', 'Primary Target
DYRK/CLK
Ethanone, 1-(5-hydroxybenzo[b]thien-2-yl)- Preparation Products And Raw materials
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