1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-4-hydroxy-

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1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-4-hydroxy- Basic information
Product Name:1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-4-hydroxy-
Synonyms:1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-4-hydroxy-;(S)-2-(2,6-Dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione;2-[(3S)-2,6-Dioxopiperidin-3-yl]-4-hydroxyisoindole-1,3-dione;2-[(3S)-2,6-dioxopiperidin-3-yl]-4-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione;(S)-Thalidomide-4-OH;2-[(3S)-2,6-Dioxo-3-piperidinyl]-4-hydroxy-1H-isoindole-1,3(2H)-dione
CAS:2357105-36-1
MF:C13H10N2O5
MW:274.23
EINECS:
Product Categories:
Mol File:2357105-36-1.mol
1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-4-hydroxy- Structure
1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-4-hydroxy- Chemical Properties
Boiling point 568.3±45.0 °C(Predicted)
density 1.611±0.06 g/cm3(Predicted)
form Solid
pka6.82±0.20(Predicted)
color Off-white to light yellow
Safety Information
MSDS Information
1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-4-hydroxy- Usage And Synthesis
Uses(S)-Thalidomide-4-OH is the S-isomer of Thalidomide-4-OH (HY-103596). Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs[1].
References[1] Marks MG, et al. Effects of putative hydroxylated thalidomide metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferation. Biol Pharm Bull. 2002 May;25(5):597-604. DOI:10.1248/bpb.25.597
1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-4-hydroxy- Preparation Products And Raw materials
Tag:1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-4-hydroxy-(2357105-36-1) Related Product Information
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