5H-Dibenzo[a,d]cycloheptene-2,8-dicarboxamide, 5-[(2S)-2-[[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethyl]amino]propyl]-10,11-dihydro-N2,N2,N8,N8-tetramethyl-5-(2H-tetrazol-5-yl)-

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5H-Dibenzo[a,d]cycloheptene-2,8-dicarboxamide, 5-[(2S)-2-[[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethyl]amino]propyl]-10,11-dihydro-N2,N2,N8,N8-tetramethyl-5-(2H-tetrazol-5-yl)- Basic information
Product Name:5H-Dibenzo[a,d]cycloheptene-2,8-dicarboxamide, 5-[(2S)-2-[[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethyl]amino]propyl]-10,11-dihydro-N2,N2,N8,N8-tetramethyl-5-(2H-tetrazol-5-yl)-
Synonyms:5H-Dibenzo[a,d]cycloheptene-2,8-dicarboxamide, 5-[(2S)-2-[[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethyl]amino]propyl]-10,11-dihydro-N2,N2,N8,N8-tetramethyl-5-(2H-tetrazol-5-yl)-;ALS-20426;ALS-2-0426;ALS-2-0426 free base;AMG 222;AMG222;AMG-222
CAS:913978-37-7
MF:C32H39N9O3
MW:597.71
EINECS:
Product Categories:
Mol File:913978-37-7.mol
5H-Dibenzo[a,d]cycloheptene-2,8-dicarboxamide, 5-[(2S)-2-[[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethyl]amino]propyl]-10,11-dihydro-N2,N2,N8,N8-tetramethyl-5-(2H-tetrazol-5-yl)- Structure
5H-Dibenzo[a,d]cycloheptene-2,8-dicarboxamide, 5-[(2S)-2-[[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethyl]amino]propyl]-10,11-dihydro-N2,N2,N8,N8-tetramethyl-5-(2H-tetrazol-5-yl)- Chemical Properties
Boiling point 869.6±75.0 °C(Predicted)
density 1.33±0.1 g/cm3(Predicted)
pka4.39±0.10(Predicted)
Safety Information
MSDS Information
5H-Dibenzo[a,d]cycloheptene-2,8-dicarboxamide, 5-[(2S)-2-[[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethyl]amino]propyl]-10,11-dihydro-N2,N2,N8,N8-tetramethyl-5-(2H-tetrazol-5-yl)- Usage And Synthesis
UsesAMG-222 is a dipeptidyl peptidase IV (DPP-IV) inhibitor that exerts its inhibitory effect by tightly and reversibly binding to DPPIV. AMG 222 binds to human plasma proteins in a saturable and concentration-dependent manner, with a binding rate of 80.8% at 1 nM, while the binding rate decreases to 29.4% at concentrations above 100 nM. AMG-222 can be used in research related to diabetes[1].
IC 50DPP-4
References[1] Greene R J, et al. Target-mediated metabolism and target-mediated drug disposition of the DPPIV inhibitor AMG 222[J]. Xenobiotica, 2011, 41(11): 945-957. DOI:10.3109/00498254.2011.597455
5H-Dibenzo[a,d]cycloheptene-2,8-dicarboxamide, 5-[(2S)-2-[[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethyl]amino]propyl]-10,11-dihydro-N2,N2,N8,N8-tetramethyl-5-(2H-tetrazol-5-yl)- Preparation Products And Raw materials
Tag:5H-Dibenzo[a,d]cycloheptene-2,8-dicarboxamide, 5-[(2S)-2-[[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethyl]amino]propyl]-10,11-dihydro-N2,N2,N8,N8-tetramethyl-5-(2H-tetrazol-5-yl)-(913978-37-7) Related Product Information
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