| Company Name: |
Ascent Scientific |
| Tel: |
4401179829988 |
| Email: |
customerservice@ascentscientific.co.uk |
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| | AmN082 dihydrochloride Basic information |
| Product Name: | AmN082 dihydrochloride | | Synonyms: | AMN 082;N,N'-DIBENZHYDRYLETHANE-1,2-DIAMINE DIHYDROCHLORIDE;N,N'-BIS(DIPHENYLMETHYL)-1,2-ETHANEDIAMINE DIHYDROCHLORIDE;N,N'-Bis(diphenylmethyl)-1,2-ethandiamine dihydrochloride;N,N'-bis(diphenylMethyl)ethylenediaMine;AMN 082 dihydrochlor;AMN082 free base;locomotor,allosteric,AMN082 free base,AMN 082,blood-brain,stress,hormone,Inhibitor,AMN-082,inhibit,sensitization,AMN-082 free base,oral,Metabotropic glutamate receptors,mGluR,barrier | | CAS: | 83027-13-8 | | MF: | C28H28N2 | | MW: | 392.54 | | EINECS: | | | Product Categories: | Glutamate;Glutamate receptor | | Mol File: | 83027-13-8.mol |  |
| | AmN082 dihydrochloride Chemical Properties |
| Melting point | 105.5 °C | | Boiling point | 533.7±45.0 °C(Predicted) | | density | 1.086±0.06 g/cm3(Predicted) | | storage temp. | Desiccate at +4°C | | solubility | DMSO : 12.5 mg/mL (31.84 mM; ultrasonic and warming and heat to 60°C) | | pka | 8.38±0.29(Predicted) | | form | Solid | | color | White to off-white |
| | AmN082 dihydrochloride Usage And Synthesis |
| Uses | AMN082 dihydrochloride is a selective agonist at mGluR-7. | | Definition | ChEBI: N,N'-bis(diphenylmethyl)ethane-1,2-diamine is a diamine that is ethane-1,2-diamine in which both amino groups are substituted by diphenylmethyl groups. It is an allosteric agonist of the metabotropic glutamate receptor 7 (mGluR7). It has a role as a metabotropic glutamate receptor agonist and a neuroprotective agent. It is a diarylmethane, a secondary amino compound, a diamine and a member of benzenes. It is a conjugate base of a N,N'-bis(diphenylmethyl)ethane-1,2-diamine(2+). | | Biological Activity | The first selective mGlu 7 agonist. Potently inhibits cAMP accumulation and stimulates GTP γ S binding in recombinant cells and on membranes expressing mGlu 7 (EC 50 = 64-290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 μ M. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats. | | in vivo | AMN082 (6 mg/kg; p.o.) induces stress hormone increases in an mGluR7-dependent fashion in mGluR7+/+ mice (C57BL/6 genetic background)[1].
AMN082 (1.25-5.0 mg/kg, i.p.; 30 min before every Cocaine injection during repeated drug administration or before Cocaine challenge) dose-dependently attenuates the development, as well as the expression of Cocaine locomotor sensitization[3]. |
| | AmN082 dihydrochloride Preparation Products And Raw materials |
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