4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)-

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4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)- Suppliers list
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Company Name: TargetMol Chemicals Inc.  
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Company Name: TargetMol Chemicals Inc.  
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Email: marketing@targetmol.com

4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)- manufacturers

  • PI3K-IN-2
  • PI3K-IN-2 pictures
  • $3520.00
  • 2026-04-21
  • CAS:1403458-28-5
  • Purity:
  • Supply Ability: 10g
4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)- Basic information
Product Name:4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)-
Synonyms:4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)-
CAS:1403458-28-5
MF:C28H29F2N3O5
MW:525.54
EINECS:
Product Categories:
Mol File:1403458-28-5.mol
4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)- Structure
4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)- Chemical Properties
Boiling point 721.0±60.0 °C(Predicted)
density 1.380±0.06 g/cm3(Predicted)
pka2.35±0.60(Predicted)
Safety Information
MSDS Information
4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)- Usage And Synthesis
UsesPI3K-IN-2 (compound 10) is a potent and orally active PI3Kβ/δ (IC50=7.1/8.6 nM) inhibitor with excellent selectivity versus PI3Kσ and PI3Kγ (IC50=13/190 nM, respectively)[1].
in vivo

PI3K-IN-2 shows profound pharmacodynamic modulation of AKT phosphorylation in PTEN-deficient PC3 prostate tumour bearing mice after oral administration and gave significant inhibition of tumour growth in the same xenograft model[1].

IC 50PI3Kα: 13 nM (IC50); PI3Kβ: 7.1 nM (IC50); PI3Kδ: 190 nM (IC50); PI3Kγ: 8.6 nM (IC50)
References[1] Barlaam B, et al. Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours. Bioorg Med Chem Lett. 2017 May 1;27(9):1949-1954. DOI:10.1016/j.bmcl.2017.03.027
4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)- Preparation Products And Raw materials
Tag:4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)-(1403458-28-5) Related Product Information
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