Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl-
| 中文名称 | Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl- |
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| 中文同义词 | 萨力多胺-O-酰胺-四聚乙二醇-炔;沙利度胺-O-酰胺-四聚乙二醇-炔;2-((2-(2,6-二氧代哌啶-3-基)-1,3-二氧代异吲哚啉-4-基)氧基)-N-(3,6,9,12-四氧杂十五碳-14-炔-1-基)乙酰胺 |
| 英文名称 | Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl- |
| 英文同义词 | Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl-;2-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]oxy-N-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethyl]acetamide;2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-N-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)acetamide;2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-N-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)acetamide?, Thalidomide-O-amido-PEG4-propargyl;2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-ylacetamide |
| CAS号 | 2496687-00-2 |
| 分子式 | C26H31N3O10 |
| 分子量 | 545.54 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2496687-00-2.mol |
| 结构式 | ![Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl- 结构式](CAS/20210305/GIF/2496687-00-2.gif) |
Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl- 性质
| 沸点 | 787.7±60.0 °C(Predicted) |
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| 密度 | 1.334±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C, stored under nitrogen, away from moisture |
| 形态 | Oil |
| 酸度系数(pKa) | 10.68±0.40(Predicted) |
| 颜色 | Colorless to light yellow |
Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl- 用途与合成方法
Thalidomide-O-amido-PEG4-propargyl 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。Thalidomide-O-amido-PEG4-propargyl 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。