3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-

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3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]- Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
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Products Intro: Product Name:VU0360172；VU 0360172;VU-0360172
CAS:1310012-12-4
Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 13816613772
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Products Intro: Product Name:VU0360172
CAS:1310012-12-4
Purity:98% Package:1g
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Tel: 021-61312847; 18021002903
Email: 3008007409@qq.com
Products Intro: Product Name:VU0360172
CAS:1310012-12-4
Purity:98% Package:5mg Remarks:S89806
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: QQ：65489617 19372819560
Email: Sales@ATKchemical.com
Products Intro: Product Name:VU0360172
CAS:1310012-12-4
Purity:98 Package:1G,5G,10G,50G,100G,500G
Company Name: Jingmo (Xiamen) Biotechnology Co., Ltd  
Tel: 13621943973; 13621943973
Email: sales@jamxmpharmatech.com
Products Intro: Product Name:VU0360172
CAS:1310012-12-4
Purity:96% Package:1g;5g;10g
3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]- Basic information
Product Name:3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-
Synonyms:3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-;VU0360172,CD1 mice,Metabotropic glutamate receptors,Polyphosphoinositide,Inhibitor,PI hydrolysis,mGluR,inhibit;VU0360172, 10 mM in DMSO
CAS:1310012-12-4
MF:C18H15FN2O
MW:294.32
EINECS:
Product Categories:
Mol File:1310012-12-4.mol
3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]- Structure
3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]- Chemical Properties
Boiling point 506.8±45.0 °C(Predicted)
density 1.27±0.1 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO : 83.33 mg/mL (283.13 mM; Need ultrasonic)
pka13.78±0.20(Predicted)
form Solid
color Light yellow to brown
Safety Information
MSDS Information
3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]- Usage And Synthesis
UsesVU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1]. VU0360172 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Biological ActivityVU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1].
IC 50mGluR5: 16 nM (EC50); mGluR5: 195 nM (Ki)
References[1]. Zuena AR, et al. In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator. Front Pharmacol. 2018 Jul 31;9:804.
3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]- Preparation Products And Raw materials
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